{"id":1590,"date":"2026-08-14T08:41:50","date_gmt":"2026-08-13T23:41:50","guid":{"rendered":"https:\/\/wewellinfo.com\/jp\/uncategorized\/hangover-acetaminophen-liver-risk\/"},"modified":"2026-08-14T08:41:50","modified_gmt":"2026-08-13T23:41:50","slug":"hangover-acetaminophen-liver-risk","status":"publish","type":"post","link":"https:\/\/wewellinfo.com\/jp\/men-health\/hangover-acetaminophen-liver-risk\/","title":{"rendered":"\u4e8c\u65e5\u9154\u3044\u3068\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\uff5c\u809d\u81d3\u306b\u8ca0\u62c5\u304c\u96c6\u307e\u308b3\u6761\u4ef6"},"content":{"rendered":"<p>\u6b63\u76f4\u306b\u7533\u3057\u4e0a\u3052\u307e\u3059\u3068\u3001\u79c1\u306f\u9577\u3044\u3042\u3044\u3060\u3001<strong>\u4e8c\u65e5\u9154\u3044<\/strong>\u306e\u671d\u306b\u85ac\u7bb1\u3092\u958b\u3051\u308b\u3053\u3068\u3092\u300c\u5f53\u7136\u306e\u5fdc\u6025\u51e6\u7f6e\u300d\u3060\u3068\u601d\u3063\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u982d\u304c\u5272\u308c\u305d\u3046\u3067\u3001\u80c3\u306f\u3080\u304b\u3064\u304f\u3002\u3068\u308a\u3042\u3048\u305a\u4f55\u304b\u98f2\u3093\u3067\u3001\u5348\u524d\u4e2d\u3092\u3084\u308a\u904e\u3054\u3057\u305f\u3044\u3002\u305d\u306e\u9806\u756a\u306b\u3001\u7591\u554f\u3092\u6301\u3063\u305f\u3053\u3068\u304c\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u306d\u3002<\/p>\n<p>\u3068\u3053\u308d\u304c\u3001\u516c\u7684\u8cc7\u6599\u3068\u67fb\u8aad\u8ad6\u6587\u3092\u4e26\u3079\u3066\u8aad\u307f\u76f4\u3057\u3066\u307f\u308b\u3068\u3001\u524d\u63d0\u306e\u307b\u3046\u304c\u5148\u306b\u5d29\u308c\u3066\u3044\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u7d50\u8ad6\u304b\u3089\u7533\u3057\u4e0a\u3052\u307e\u3059\u3002<strong>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3<\/strong>\u306f\u3001\u7528\u6cd5\u7528\u91cf\u3092\u5b88\u308c\u3070\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b\u85ac\u3067\u3059\u3002\u300c\u4e00\u6669\u98f2\u3093\u3060\u7fcc\u671d\u306b\u4e00\u5ea6\u98f2\u3093\u3060\u3089\u809d\u4e0d\u5168\u306b\u306a\u308b\u300d\u3068\u3044\u3046\u8a71\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u305f\u3060\u3057\u3001<strong>\u2460\u65e5\u5e38\u7684\u306b\u591a\u91cf\u306b\u98f2\u9152\u3057\u3066\u3044\u308b \u2461\u524d\u591c\u304b\u3089\u4f55\u3082\u98df\u3079\u3066\u3044\u306a\u3044 \u2462\u8907\u6570\u306e\u5e02\u8ca9\u85ac\u306b\u540c\u3058\u6210\u5206\u304c\u91cd\u306a\u3063\u3066\u3044\u308b<\/strong> \u2014 \u3053\u306e3\u3064\u304c\u305d\u308d\u3046\u3068\u3001\u809d\u81d3\u306b\u3068\u3063\u3066\u6761\u4ef6\u304c\u306f\u3063\u304d\u308a\u60aa\u304f\u306a\u308a\u307e\u3059\u3002\u305d\u3057\u3066\u98f2\u9152\u306e\u7fcc\u671d\u306f\u3001\u305d\u306e3\u3064\u304c\u540c\u6642\u306b\u6210\u7acb\u3057\u3084\u3059\u3044\u671d\u306a\u306e\u3067\u3059\u3002<\/p>\n<p>\u3082\u3046\u3072\u3068\u3064\u3001\u5148\u306b\u304a\u4f1d\u3048\u3057\u305f\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u7fcc\u671d\u306e\u4e8c\u65e5\u9154\u3044\u306f\u3001\u300c\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u305b\u3044\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong><\/p>\n<p>\u3053\u306e\u8a18\u4e8b\u3067\u306f\u3001\u539a\u751f\u52b4\u50cd\u7701 e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u3001PMDA \u306e\u6dfb\u4ed8\u6587\u66f8\u3001MSD\u30de\u30cb\u30e5\u30a2\u30eb\u3001\u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u3001\u4e45\u91cc\u6d5c\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u306e\u5c02\u9580\u5bb6\u30b3\u30e1\u30f3\u30c8\u3001\u305d\u3057\u3066 BMJ\u30fbAddiction\u30fbJ Clin Med\u30fbScience Advances \u306b\u63b2\u8f09\u3055\u308c\u305f\u8ad6\u6587\u3067\u78ba\u8a8d\u3067\u304d\u305f\u5185\u5bb9\u3060\u3051\u3092\u4f7f\u3063\u3066\u3001\u4e8c\u65e5\u9154\u3044\u306e\u671d\u306b\u8d77\u304d\u3066\u3044\u308b\u3053\u3068\u3092\u6574\u7406\u3057\u76f4\u3057\u307e\u3059\u3002\u671f\u5f85\u5916\u308c\u3060\u3063\u305f\u3068\u3053\u308d\u3082\u3001\u601d\u3063\u3066\u3044\u305f\u3088\u308a\u91cd\u304b\u3063\u305f\u3068\u3053\u308d\u3082\u3001\u305d\u306e\u307e\u307e\u66f8\u304d\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u672c\u8a18\u4e8b\u306f\u4e00\u822c\u7684\u306a\u5065\u5eb7\u60c5\u5831\u3067\u3042\u308a\u3001\u8a3a\u65ad\u30fb\u6cbb\u7642\u30fb\u670d\u85ac\u6307\u5c0e\u306e\u4ee3\u308f\u308a\u306b\u306f\u306a\u308a\u307e\u305b\u3093\u3002\u85ac\u306e\u4f7f\u7528\u306f\u6dfb\u4ed8\u6587\u66f8\u306b\u5f93\u3044\u3001\u8ff7\u3046\u5834\u5408\u306f\u533b\u5e2b\u30fb\u85ac\u5264\u5e2b\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u660e\u308b\u3044\u6728\u306e\u30c6\u30fc\u30d6\u30eb\u306b\u7f6e\u304b\u308c\u305f\u3001\u6e6f\u6c17\u306e\u7acb\u3064\u6c41\u7269\u306e\u6900\u3068\u548c\u98df\u306e\u81b3\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-1-9.jpg\" \/><\/p>\n<p><em>Photo: Marina Endzhirgli \/ Pexels<\/em><\/p>\n<h2>\u307e\u305a\u8a02\u6b63\u304b\u3089 \u2014 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\u3089\u30019(7):2081\uff09\u306f\u3001\u3053\u3046\u8a18\u3057\u3066\u3044\u307e\u3059\u3002\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u306f\u98f2\u9152\u5f8c\u306e\u65e9\u3044\u6642\u9593\u5e2f\u306b\u30d4\u30fc\u30af\u306b\u9054\u3057\u3001\u6025\u901f\u306b\u4f4e\u4e0b\u3059\u308b\u3002\u3042\u308b\u7814\u7a76\u3067\u306f<strong>\u6442\u53d612\u6642\u9593\u5f8c\u306b\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306f\u3082\u306f\u3084\u691c\u51fa\u3067\u304d\u306a\u304b\u3063\u305f<\/strong>\u4e00\u65b9\u3067\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u306f\u307e\u3060\u691c\u51fa\u3055\u308c\u305f\u3001\u3068\u3002\u4e8c\u65e5\u9154\u3044\u306e\u75c7\u72b6\u306f\u8840\u4e2d\u30a2\u30eb\u30b3\u30fc\u30eb\u6fc3\u5ea6\u304c\u30bc\u30ed\u306b\u8fd1\u3065\u304f\u9803\u306b\u73fe\u308c\u307e\u3059\u3002\u3064\u307e\u308a\u75c7\u72b6\u306e\u30d4\u30fc\u30af\u6642\u306b\u306f\u3001\u72af\u4eba\u3068\u3055\u308c\u308b\u7269\u8cea\u306f\u73fe\u5834\u304b\u3089\u3044\u306a\u304f\u306a\u3063\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u306d\u3002<\/p>\n<p>\u4e45\u91cc\u6d5c\u533b\u7642\u30bb\u30f3\u30bf\u30fc 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ALDH2 \u306e\u50cd\u304d\u304c\u5f31\u3044\u4f53\u8cea\uff09<\/td>\n<td>\u307b\u307c\u691c\u51fa\u3055\u308c\u306a\u3044<\/td>\n<\/tr>\n<tr>\n<td>\u4e3b\u306a\u539f\u56e0<\/td>\n<td>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u84c4\u7a4d\u306b\u3088\u308b<strong>\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc<\/strong>\uff08\u9854\u9762\u7d05\u6f6e\u30fb\u52d5\u60b8\u30fb\u982d\u75db\u30fb\u5410\u304d\u6c17\uff09<\/td>\n<td>\u8131\u6c34\u30fb\u4f4e\u8840\u7cd6\u30fb\u708e\u75c7\u30fb\u80c3\u7c98\u819c\u969c\u5bb3\u30fb\u6b8b\u5b58\u30a8\u30bf\u30ce\u30fc\u30eb\u7b49\u306e<strong>\u591a\u56e0\u5b50<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>\u300c\u9854\u304c\u8d64\u304f\u306a\u308b\u306e\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u300d\u306f\u6b63\u3057\u3044\u3002\u300c\u7fcc\u671d\u306e\u4e8c\u65e5\u9154\u3044\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u300d\u306f\u6b63\u3057\u304f\u306a\u3044\u3002<\/strong> \u3053\u306e\u7dda\u5f15\u304d\u304c\u3001\u3053\u306e\u5148\u306e\u8a71\u306e\u571f\u53f0\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u304c\u98f2\u9152\u5f8c\u65e9\u671f\u306b\u30d4\u30fc\u30af\u3092\u8fce\u3048\u6025\u964d\u4e0b\u3059\u308b\u3053\u3068\u3092\u793a\u3059\u66f2\u7dda\u3068\u3001\u98f2\u9152\u4e2d\u301c\u76f4\u5f8c\uff0f\u7fcc\u671d\u306e\u539f\u56e0\u306e\u5bfe\u6bd4\u56f3\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-2-14.png\" \/><\/p>\n<h3>\u3067\u306f\u7fcc\u671d\u3001\u5b9f\u969b\u306b\u4f55\u304c\u8d77\u304d\u3066\u3044\u308b\u306e\u304b<\/h3>\n<p>\u4e45\u91cc\u6d5c\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3068\u300eJ Clin Med\u300f2020 \u306e\u8a18\u8ff0\u304b\u3089\u6574\u7406\u3059\u308b\u3068\u3001\u3053\u3046\u306a\u308a\u307e\u3059\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u8981\u56e0<\/th>\n<th>\u5185\u5bb9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>\u8131\u6c34<\/strong><\/td>\n<td>\u6297\u5229\u5c3f\u30db\u30eb\u30e2\u30f3\uff08\u30d0\u30bd\u30d7\u30ec\u30b7\u30f3\uff09\u306e\u5206\u6ccc\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u3067\u6291\u3048\u3089\u308c\u3001\u6c34\u5206\u304c\u5c3f\u3068\u3057\u3066\u51fa\u3066\u3044\u304d\u3084\u3059\u304f\u306a\u308b<\/td>\n<\/tr>\n<tr>\n<td><strong>\u4f4e\u8840\u7cd6<\/strong><\/td>\n<td>\u809d\u81d3\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u5206\u89e3\u3092\u512a\u5148\u3057\u3001\u7cd6\u65b0\u751f\u304c\u6291\u5236\u3055\u308c\u308b\u3002\u4f53\u306b\u529b\u304c\u5165\u3089\u305a\u7121\u6c17\u529b\u306b\u306a\u308a\u3084\u3059\u3044<\/td>\n<\/tr>\n<tr>\n<td><strong>\u708e\u75c7\u6027\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3<\/strong><\/td>\n<td>\u30a2\u30eb\u30b3\u30fc\u30eb\u304c\u8133\u8840\u7ba1\u5468\u56f2\u3067\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u5897\u3084\u3057\u3001\u982d\u75db\u306e\u4e00\u56e0\u3068\u306a\u308b<\/td>\n<\/tr>\n<tr>\n<td><strong>\u708e\u75c7\u30de\u30fc\u30ab\u30fc\u3068\u91cd\u75c7\u5ea6\u306e\u76f8\u95a2<\/strong><\/td>\n<td>IL-6 \u306f\u4e8c\u65e5\u9154\u3044\u306e\u91cd\u75c7\u5ea6\u3068\u6709\u610f\u306b\u95a2\u9023\u3002TNF-\u03b1 \u306f\u98f2\u9152\u5f8c4\u6642\u9593\u30fb12\u6642\u9593\u306e\u4e21\u6642\u70b9\u3067\u5f37\u3044\u76f8\u95a2\u3002CRP \u306f4\u6642\u9593\u6642\u70b9\u306e\u6fc3\u5ea6\u304c\u91cd\u75c7\u5ea6\u3068\u6709\u610f\u306b\u76f8\u95a2\uff08J Clin Med 2020\uff09<\/td>\n<\/tr>\n<tr>\n<td><strong>\u80c3\u7c98\u819c\u306e\u640d\u50b7<\/strong><\/td>\n<td>\u98f2\u9152\u306b\u3088\u308a\u80c3\u7c98\u819c\u306e\u30d0\u30e9\u30f3\u30b9\u304c\u5d29\u308c\u3001\u30c0\u30e1\u30fc\u30b8\u3092\u53d7\u3051\u308b<\/td>\n<\/tr>\n<tr>\n<td><strong>congeners\uff08\u4e0d\u7d14\u7269\uff09<\/strong><\/td>\n<td>\u30e1\u30bf\u30ce\u30fc\u30eb\u7b49\u306f\u5206\u89e3\u306b\u6642\u9593\u304c\u304b\u304b\u308a\u4f53\u5185\u306b\u9577\u304f\u3068\u3069\u307e\u308b\u305f\u3081\u3001\u75b2\u52b4\u611f\u3084\u3060\u308b\u3055\u304c\u6b8b\u308b<\/td>\n<\/tr>\n<tr>\n<td><strong>\u6b8b\u5b58\u30a2\u30eb\u30b3\u30fc\u30eb<\/strong><\/td>\n<td>\u591c12\u6642\u306b50g\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u3092\u6442\u308b\u3068\u3001\u7fcc\u671d\u306e\u51fa\u52e4\u6642\u307e\u3067\u306b\u5b8c\u5168\u306b\u306f\u5206\u89e3\u3055\u308c\u306a\u3044\uff08\u4e00\u6a4b\u5927\u5b66\u4fdd\u5065\u30bb\u30f3\u30bf\u30fc\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u300eJ Clin Med\u300f2020 \u306f\u7d71\u5408\u30e2\u30c7\u30eb\u3068\u3057\u3066\u3001\u300c\u98f2\u9152\u5f8c\u6700\u521d\u306e\u6570\u6642\u9593\u3067\u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u6d88\u5931\u304c\u9045\u3044\u3068\u3001\u591c\u306e\u5f8c\u534a\u306b\u3088\u308a\u591a\u304f\u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u304c\u5b58\u5728\u3059\u308b\u3053\u3068\u306b\u306a\u308a\u3001\u3088\u308a\u5f37\u3044\u9178\u5316\u30b9\u30c8\u30ec\u30b9\u3068\u708e\u75c7\u53cd\u5fdc\u3092\u5f15\u304d\u8d77\u3053\u3059\u300d\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u8981\u3059\u308b\u306b\u3001<strong>\u5358\u4e00\u306e\u6bd2\u7d20\u306e\u554f\u984c\u3067\u306f\u306a\u304f\u3001\u4f53\u306e\u3042\u3061\u3053\u3061\u304c\u540c\u6642\u306b\u5c11\u3057\u305a\u3064\u72c2\u3063\u3066\u3044\u308b\u72b6\u614b<\/strong>\u306a\u306e\u3067\u3059\u306d\u3002<\/p>\n<p>\u3060\u304b\u3089\u300c\u305d\u306e\u6bd2\u7d20\u3092\u6d88\u3059\u4e00\u624b\u300d\u3082\u3001\u539f\u7406\u7684\u306b\u5b58\u5728\u3057\u306b\u304f\u3044\u308f\u3051\u3067\u3059\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u660e\u308b\u3044\u7a93\u8fba\u306b\u7f6e\u304b\u308c\u305f\u3001\u6c34\u3092\u5165\u308c\u305f\u30ac\u30e9\u30b9\u306e\u5668\u3068\u671d\u306e\u82b1\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-3-12.jpg\" \/><\/p>\n<p><em>Photo: Zulfugar Karimov \/ Pexels<\/em><\/p>\n<h2>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3068\u98f2\u9152 \u2014 \u4f55\u304c\u672c\u5f53\u306b\u5371\u306a\u3044\u306e\u304b<\/h2>\n<p>\u3053\u3053\u304b\u3089\u304c\u672c\u984c\u3067\u3059\u3002<\/p>\n<h3>\u809d\u81d3\u306e\u4e2d\u3067\u8d77\u304d\u3066\u3044\u308b\u3053\u3068<\/h3>\n<p>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306e\u5927\u90e8\u5206\u306f\u3001\u30b0\u30eb\u30af\u30ed\u30f3\u9178\u62b1\u5408\u30fb\u786b\u9178\u62b1\u5408\u3068\u3044\u3046\u7d4c\u8def\u3067\u7121\u6bd2\u5316\u3055\u308c\u307e\u3059\u3002\u305f\u3060\u3057\u4e00\u90e8\u306f\u809d\u81d3\u306e\u30c1\u30c8\u30af\u30ed\u30e0 P450\uff08\u4e3b\u306b <strong>CYP2E1<\/strong>\uff09\u306b\u3088\u3063\u3066\u3001<strong>NAPQI<\/strong> \u3068\u3044\u3046\u6bd2\u6027\u4ee3\u8b1d\u7269\u306b\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n<p>\u901a\u5e38\u3001\u3053\u306e NAPQI \u306f\u809d\u81d3\u306b\u84c4\u3048\u3089\u308c\u305f<strong>\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3<\/strong>\u304c\u5373\u5ea7\u306b\u89e3\u6bd2\u3057\u307e\u3059\uff08MSD\u30de\u30cb\u30e5\u30a2\u30eb \u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u7248\uff09\u3002<\/p>\n<p>\u554f\u984c\u304c\u8d77\u304d\u308b\u306e\u306f\u3001\u6b21\u306e\u6761\u4ef6\u304c\u91cd\u306a\u3063\u305f\u3068\u304d\u3067\u3059\u3002<\/p>\n<ul>\n<li><strong>\u62b1\u5408\u80fd\u306e\u98fd\u548c<\/strong> \u2014 \u904e\u91cf\u6442\u53d6\u3084\u91cd\u8907\u6295\u4e0e\u3067\u3001CYP2E1 \u7d4c\u8def\u306b\u56de\u308b\u5272\u5408\u304c\u5897\u3048\u308b<\/li>\n<li><strong>CYP2E1 \u306e\u8a98\u5c0e<\/strong> \u2014 \u6162\u6027\u7684\u306a\u591a\u91cf\u98f2\u9152\u3067\u3001NAPQI \u306e\u751f\u6210\u5272\u5408\u305d\u306e\u3082\u306e\u304c\u5897\u3048\u308b<\/li>\n<li><strong>\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u306e\u67af\u6e07<\/strong> \u2014 \u7d76\u98df\u30fb\u4f4e\u6804\u990a\u30fb\u8131\u6c34\u3067\u3001NAPQI \u3092\u6d88\u3059\u5074\u304c\u8db3\u308a\u306a\u304f\u306a\u308b<\/li>\n<\/ul>\n<p>\u305d\u306e\u7d50\u679c\u3001\u84c4\u7a4d\u3057\u305f NAPQI \u304c\u809d\u7d30\u80de\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u3068\u7d50\u5408\u3057\u3001<strong>\u809d\u7d30\u80de\u58ca\u6b7b<\/strong>\u3092\u5f15\u304d\u8d77\u3053\u3057\u307e\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001\u98f2\u9152\u306e\u7fcc\u671d\u3068\u3044\u3046\u6642\u9593\u5e2f\u3092\u601d\u3044\u6d6e\u304b\u3079\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u300c\u65e5\u5e38\u7684\u306b\u98f2\u3093\u3067\u3044\u308b\u300d\u300c\u524d\u591c\u304b\u3089\u4f55\u3082\u98df\u3079\u3066\u3044\u306a\u3044\u300d\u300c\u8131\u6c34\u3057\u3066\u3044\u308b\u300d\u304c\u3001\u540c\u6642\u306b\u6210\u7acb\u3057\u3084\u3059\u3044\u671d\u306a\u306e\u3067\u3059\u3002<\/strong><\/p>\n<p><img decoding=\"async\" alt=\"\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306e2\u3064\u306e\u4ee3\u8b1d\u7d4c\u8def\u3068\u3001CYP2E1\u8a98\u5c0e\u30fb\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u67af\u6e07\u30fb\u62b1\u5408\u98fd\u548c\u306e3\u6761\u4ef6\u304c\u91cd\u306a\u308b\u4ed5\u7d44\u307f\u306e\u56f3\u89e3\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-4-12.png\" \/><\/p>\n<h3>\u65e5\u672c\u306e\u6dfb\u4ed8\u6587\u66f8\u306b\u66f8\u304b\u308c\u3066\u3044\u308b\u3053\u3068<\/h3>\n<p>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u539f\u672b\u306e\u6dfb\u4ed8\u6587\u66f8\uff08PMDA \u53ce\u8f09\uff09\u306b\u306f\u3001\u6b21\u306e\u3088\u3046\u306a\u8a18\u8f09\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<ul>\n<li><strong>\u8b66\u544a<\/strong> \u2014 \u672c\u5264\u306b\u3088\u308a\u91cd\u7be4\u306a\u809d\u969c\u5bb3\u304c\u767a\u73fe\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3053\u3068\u306b\u6ce8\u610f\u3057\u3001\u9ad8\u7528\u91cf\u3067\u9577\u671f\u306b\u6295\u4e0e\u3059\u308b\u5834\u5408\u306b\u306f\u5b9a\u671f\u7684\u306b\u809d\u6a5f\u80fd\u7b49\u3092\u78ba\u8a8d\u3059\u308b\u306a\u3069\u614e\u91cd\u306b\u6295\u4e0e\u3059\u308b\u3053\u3068<\/li>\n<li><strong>\u8b66\u544a<\/strong> \u2014 \u672c\u5264\u3068\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u542b\u3080<strong>\u4ed6\u306e\u85ac\u5264\uff08\u4e00\u822c\u7528\u533b\u85ac\u54c1\u3092\u542b\u3080\uff09\u3068\u306e\u4f75\u7528<\/strong>\u306b\u3088\u308a\u3001\u904e\u91cf\u6295\u4e0e\u306b\u3088\u308b\u91cd\u7be4\u306a\u809d\u969c\u5bb3\u304c\u767a\u73fe\u3059\u308b\u304a\u305d\u308c\u304c\u3042\u308b\u3053\u3068\u304b\u3089\u3001\u3053\u308c\u3089\u306e\u85ac\u5264\u3068\u306e\u4f75\u7528\u3092\u907f\u3051\u308b\u3053\u3068<\/li>\n<li><strong>\u7279\u5b9a\u306e\u80cc\u666f\u3092\u6709\u3059\u308b\u60a3\u8005<\/strong> \u2014 <strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u591a\u91cf\u5e38\u98f2\u8005<\/strong>\u306f\u300c\u809d\u969c\u5bb3\u304c\u3042\u3089\u308f\u308c\u3084\u3059\u304f\u306a\u308b\u300d<\/li>\n<li><strong>\u540c\u9805<\/strong> \u2014 \u6804\u990a\u4e0d\u826f\u60a3\u8005\u3001<strong>\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u6b20\u4e4f<\/strong>\u3001\u8131\u6c34\u75c7\u72b6\u306e\u3042\u308b\u60a3\u8005\u306f\u809d\u969c\u5bb3\u306e\u30ea\u30b9\u30af\u304c\u5897\u52a0\u3059\u308b<\/li>\n<li><strong>\u4f75\u7528\u6ce8\u610f<\/strong> \u2014 \u300c<strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u591a\u91cf\u5e38\u98f2\u8005\u304c\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u670d\u7528\u3057\u305f\u3068\u3053\u308d\u809d\u4e0d\u5168\u3092\u8d77\u3053\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b<\/strong>\u300d<\/li>\n<li><strong>\u91cd\u5927\u306a\u526f\u4f5c\u7528<\/strong> \u2014 \u5287\u75c7\u809d\u708e\u3001AST\u30fbALT\u30fb\u03b3-GTP \u306e\u4e0a\u6607\u7b49\u3092\u4f34\u3046\u809d\u6a5f\u80fd\u969c\u5bb3\u3001\u9ec4\u75b8\u304c\u3042\u3089\u308f\u308c\u308b\u3053\u3068\u304c\u3042\u308b<\/li>\n<\/ul>\n<p>\u8aad\u3093\u3067\u3044\u3066\u3001\u80cc\u7b4b\u304c\u4f38\u3073\u308b\u6587\u9762\u3067\u306f\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u305f\u3060\u3001\u3053\u3053\u3067\u6b62\u3081\u308b\u3068\u8a18\u4e8b\u306e\u307b\u3046\u304c\u8aa4\u60c5\u5831\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n<h3>\u30d0\u30e9\u30f3\u30b9\u3092\u53d6\u308a\u307e\u3059 \u2014 \u300c\u7fcc\u671d\u306e1\u56de\u3067\u809d\u4e0d\u5168\u300d\u3067\u306f\u3042\u308a\u307e\u305b\u3093<\/h3>\n<p>MSD\u30de\u30cb\u30e5\u30a2\u30eb \u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u7248\u306f\u3001\u3053\u306e\u8ad6\u70b9\u306b\u3064\u3044\u30662\u3064\u306e\u5074\u9762\u3092\u4e26\u3079\u3066\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u7406\u8ad6\u7684\u306a\u5074\u9762\u3068\u3057\u3066\u306f\u3001\u300c\u809d\u9175\u7d20\u306e\u30d7\u30ec\u30b3\u30f3\u30c7\u30a3\u30b7\u30e7\u30cb\u30f3\u30b0\u306f NAPQI \u751f\u6210\u3092\u5897\u52a0\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u4f4e\u6804\u990a\uff08\u3053\u308c\u3082\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u60a3\u8005\u3067\u4e00\u822c\u7684\u3067\u3042\u308b\uff09\u306f\u809d\u81d3\u306e\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u8caf\u8535\u3092\u4f4e\u4e0b\u3055\u305b\u308b\u305f\u3081\u3001\u7406\u8ad6\u7684\u306b\u306f\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3\u307e\u305f\u306f\u4f4e\u6804\u990a\u304c\u3042\u308b\u3068\u6bd2\u6027\u306e\u30ea\u30b9\u30af\u304c\u5897\u5927\u3059\u308b\u3053\u3068\u306b\u306a\u308b\u300d\u3002<\/p>\n<p>\u3057\u304b\u3057\u81e8\u5e8a\u7684\u306a\u5074\u9762\u3068\u3057\u3066\u306f\u3001\u3053\u3046\u3082\u660e\u8a18\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<blockquote>\n<p><strong>\u300c\u305f\u3060\u3057\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u4f9d\u5b58\u75c7\u60a3\u8005\u3078\u306e\u6cbb\u7642\u91cf\u306e\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u6295\u4e0e\u304c\u809d\u969c\u5bb3\u3068\u95a2\u9023\u3059\u308b\u3053\u3068\u306f\u306a\u3044\u300d<\/strong><\/p>\n<\/blockquote>\n<p>\u65e5\u672c\u306e\u6dfb\u4ed8\u6587\u66f8\u306f\u300c\u809d\u4e0d\u5168\u3092\u8d77\u3053\u3057\u305f\u3068\u306e\u5831\u544a\u304c\u3042\u308b\u300d\u3068\u75c7\u4f8b\u5831\u544a\u3092\u6839\u62e0\u306b\u6ce8\u610f\u559a\u8d77\u3057\u3001MSD\u30de\u30cb\u30e5\u30a2\u30eb\u306f\u300c\u6cbb\u7642\u91cf\u3067\u306f\u95a2\u9023\u3057\u306a\u3044\u300d\u3068\u66f8\u304f\u3002\u4e00\u898b\u3059\u308b\u3068\u98df\u3044\u9055\u3063\u3066\u898b\u3048\u307e\u3059\u3002<\/p>\n<p>\u3051\u308c\u3069\u3001<strong>\u3053\u306e2\u3064\u306f\u77db\u76fe\u3057\u3066\u3044\u306a\u3044\u306e\u3067\u3059\u306d\u3002<\/strong><\/p>\n<p>\u96c6\u56e3\u30ec\u30d9\u30eb\u3067\u898b\u308c\u3070\u3001\u7528\u6cd5\u7528\u91cf\u3092\u5b88\u3063\u305f\u7bc4\u56f2\u3067\u306e\u95a2\u9023\u306f\u793a\u3055\u308c\u3066\u3044\u306a\u3044\u3002\u4e00\u65b9\u3067\u500b\u5225\u306e\u75c7\u4f8b\u3068\u3057\u3066\u306f\u3001\u6162\u6027\u591a\u91cf\u98f2\u9152\u30fb\u7d76\u98df\u30fb\u91cd\u8907\u6295\u4e0e\u304c\u91cd\u306a\u3063\u305f\u3068\u304d\u306b\u91cd\u7be4\u4f8b\u304c\u8d77\u304d\u3066\u3044\u308b\u3002\u305d\u3046\u8aad\u3080\u306e\u304c\u59a5\u5f53\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u3067\u3059\u304b\u3089\u3001\u3053\u306e\u8a18\u4e8b\u306e\u7acb\u5834\u306f\u3053\u3046\u3067\u3059\u3002<\/p>\n<p><strong>\u300c\u4e8c\u65e5\u9154\u3044\u306b\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u98f2\u3080\u3068\u809d\u4e0d\u5168\u306b\u306a\u308b\u300d\u306f\u3001\u8a87\u5f35\u3067\u3042\u308a\u8aa4\u308a\u3067\u3059\u3002<\/strong><\/p>\n<p><strong>\u300c\u98f2\u9152\u5f8c\u306e\u671d\u306f\u3001\u3053\u306e\u85ac\u306b\u3068\u3063\u3066\u6761\u4ef6\u304c\u3044\u3061\u3070\u3093\u60aa\u304f\u306a\u308a\u3046\u308b\u30bf\u30a4\u30df\u30f3\u30b0\u3060\u300d\u304c\u3001\u6b63\u78ba\u306a\u8a00\u3044\u65b9\u3067\u3059\u3002<\/strong><\/p>\n<h3>\u3044\u3061\u3070\u3093\u5b9f\u7528\u7684\u306a\u6ce8\u610f\u306f\u3001\u5b9f\u306f\u300c\u91cd\u8907\u300d\u3067\u3059<\/h3>\n<p>\u4e0a\u306e\u8b66\u544a\u306e\u306a\u304b\u3067\u3001\u65e5\u5e38\u3067\u3082\u3063\u3068\u3082\u5f79\u306b\u7acb\u3064\u306e\u306f<strong>\u4ed6\u306e\u85ac\u5264\u3068\u306e\u4f75\u7528\u3092\u907f\u3051\u308b\u3053\u3068<\/strong>\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u7dcf\u5408\u611f\u5192\u85ac\u3001\u89e3\u71b1\u93ae\u75db\u85ac\u3001\u9f3b\u708e\u85ac\u3002\u3053\u308c\u3089\u306b\u540c\u3058\u6210\u5206\u304c\u91cd\u8907\u3057\u3066\u542b\u307e\u308c\u3066\u3044\u308b\u3053\u3068\u306f\u73cd\u3057\u304f\u3042\u308a\u307e\u305b\u3093\u3002\u300c\u4e8c\u65e5\u9154\u3044\u3067\u982d\u304c\u75db\u3044\u3001\u3057\u304b\u3082\u98a8\u90aa\u6c17\u5473\u3060\u300d\u3068\u8907\u6570\u3092\u98f2\u3080\u3068\u3001\u672c\u4eba\u306e\u81ea\u899a\u304c\u306a\u3044\u307e\u307e\u91cf\u304c\u7a4d\u307f\u4e0a\u304c\u308a\u307e\u3059\u3002<\/p>\n<p>\u7528\u91cf\u306e\u8a71\u306f\u66f8\u304d\u307e\u305b\u3093\u3002\u66f8\u304f\u3079\u304d\u306a\u306e\u306f\u3001\u6b21\u306e3\u3064\u3060\u3051\u3067\u3059\u3002<\/p>\n<ul>\n<li><strong>\u6dfb\u4ed8\u6587\u66f8\u306b\u66f8\u304b\u308c\u305f\u4e0a\u9650\u3092\u8d85\u3048\u306a\u3044\u3053\u3068<\/strong><\/li>\n<li><strong>\u540c\u3058\u6210\u5206\u304c\u8907\u6570\u306e\u5e02\u8ca9\u85ac\u306b\u5165\u3063\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u308b\u306e\u3067\u3001\u91cd\u306d\u306a\u3044\u3053\u3068<\/strong><\/li>\n<li><strong>\u85ac\u5264\u5e2b\u306b\u98f2\u9152\u7fd2\u6163\u3092\u4f1d\u3048\u3066\u76f8\u8ac7\u3059\u308b\u3053\u3068<\/strong><\/li>\n<\/ul>\n<p>\u85ac\u5c40\u3067\u300c\u666e\u6bb5\u3069\u306e\u304f\u3089\u3044\u304a\u9152\u3092\u98f2\u307e\u308c\u307e\u3059\u304b\u300d\u3068\u805e\u304b\u308c\u305f\u3089\u3001\u6b63\u76f4\u306b\u7b54\u3048\u3066\u304f\u3060\u3055\u3044\u3002\u3042\u308c\u306f\u8aac\u6559\u306e\u305f\u3081\u306e\u8cea\u554f\u3067\u306f\u306a\u304f\u3001\u3053\u3046\u3044\u3046\u6210\u5206\u306e\u91cd\u306a\u308a\u3092\u898b\u308b\u305f\u3081\u306e\u8cea\u554f\u3067\u3059\u304b\u3089\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u660e\u308b\u3044\u5c4b\u5916\u306e\u5e2d\u3067\u3001\u66f8\u985e\u306b\u76ee\u3092\u901a\u3057\u306a\u304c\u3089\u30da\u30f3\u3067\u66f8\u304d\u8fbc\u3093\u3067\u3044\u308b\u6771\u30a2\u30b8\u30a2\u7cfb\u306e\u7537\u6027\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-5-13.jpg\" \/><\/p>\n<p><em>Photo: Armin  Rimoldi \/ Pexels<\/em><\/p>\n<h2>\u300c\u9759\u304b\u306b\u58ca\u3059\u300d\u306e\u5b9f\u4f53 \u2014 \u521d\u671f\u75c7\u72b6\u304c\u4e8c\u65e5\u9154\u3044\u3068\u898b\u5206\u3051\u304c\u3064\u304b\u306a\u3044<\/h2>\n<p>\u3053\u306e\u8a18\u4e8b\u3067\u3044\u3061\u3070\u3093\u304a\u4f1d\u3048\u3057\u305f\u3044\u306e\u306f\u3001\u3053\u3053\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002<\/p>\n<p>MSD\u30de\u30cb\u30e5\u30a2\u30eb \u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u7248\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u4e2d\u6bd2\u306e\u7d4c\u904e\u30924\u3064\u306e\u75c5\u671f\u306b\u5206\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u75c5\u671f<\/th>\n<th>\u6642\u9593<\/th>\n<th>\u75c7\u72b6<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>I<\/td>\n<td>0\u301c24\u6642\u9593<\/td>\n<td><strong>\u98df\u6b32\u4e0d\u632f\u3001\u60aa\u5fc3\u3001\u5614\u5410<\/strong><\/td>\n<\/tr>\n<tr>\n<td>II<\/td>\n<td>24\u301c72\u6642\u9593<\/td>\n<td>\u53f3\u4e0a\u8179\u90e8\u75db\uff08\u4e00\u822c\u7684\uff09\u3001\u809d\u9175\u7d20\u306e\u4e0a\u6607<\/td>\n<\/tr>\n<tr>\n<td>III<\/td>\n<td>72\u301c96\u6642\u9593<\/td>\n<td>\u5614\u5410\u304a\u3088\u3073\u809d\u4e0d\u5168\u75c7\u72b6\u3001\u809d\u9175\u7d20\u304c\u30d4\u30fc\u30af\u306b<\/td>\n<\/tr>\n<tr>\n<td>IV<\/td>\n<td>5\u65e5\u76ee\u4ee5\u964d<\/td>\n<td>\u809d\u6bd2\u6027\u304c\u6d88\u5931\u3001\u307e\u305f\u306f\u591a\u81d3\u5668\u4e0d\u5168\u306b\u9032\u884c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u3082\u3046\u4e00\u5ea6\u3001\u7b2cI\u671f\u306e\u6b04\u3092\u898b\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>\u98df\u6b32\u4e0d\u632f\u3001\u60aa\u5fc3\u3001\u5614\u5410\u3002<\/strong><\/p>\n<p>\u4e8c\u65e5\u9154\u3044\u306e\u75c7\u72b6\u3068\u3001\u307e\u3063\u305f\u304f\u898b\u5206\u3051\u304c\u3064\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u3055\u3089\u306b\u540c\u30de\u30cb\u30e5\u30a2\u30eb\u306f\u3001\u300c\u8efd\u5ea6\u306e\u4e2d\u6bd2\u306f\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3055\u306a\u3044\u5834\u5408\u304c\u3042\u308a\u3001\u75c7\u72b6\u304c\u3042\u308b\u5834\u5408\u306f\u901a\u5e38\u3001<strong>\u6442\u53d6\u5f8c48\u6642\u9593\u307e\u3067\u306f\u75c7\u72b6\u306f\u8efd\u5fae<\/strong>\u3067\u3042\u308b\u300d\u3068\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3064\u307e\u308a\u3001\u3053\u3046\u3044\u3046\u69cb\u56f3\u304c\u6210\u7acb\u3057\u3066\u3057\u307e\u3046\u306e\u3067\u3059\u306d\u3002<\/p>\n<p>\u6c17\u6301\u3061\u60aa\u3044\u3002\u3067\u3082\u6628\u65e5\u3042\u308c\u3060\u3051\u98f2\u3093\u3060\u306e\u3060\u304b\u3089\u5f53\u305f\u308a\u524d\u3060\u3002\u305d\u3046\u89e3\u91c8\u3057\u3066\u3001\u6a2a\u306b\u306a\u3063\u3066\u3001\u6642\u9593\u304c\u904e\u304e\u3066\u3044\u304f\u3002<\/p>\n<p>\u89e3\u6bd2\u5264\uff08N-\u30a2\u30bb\u30c1\u30eb\u30b7\u30b9\u30c6\u30a4\u30f3\uff09\u306f\u3001NAPQI \u304c\u809d\u7d30\u80de\u3092\u50b7\u5bb3\u3059\u308b\u524d\u306b\u50cd\u304d\u307e\u3059\u3002\u3067\u3059\u304b\u3089<strong>\u6642\u9593\u304c\u6c7a\u5b9a\u7684\u306b\u91cd\u8981<\/strong>\u3067\u3059\u3002\u305d\u308c\u306a\u306e\u306b\u3001\u3044\u3061\u3070\u3093\u6642\u9593\u304c\u60dc\u3057\u3044\u6700\u521d\u306e24\u6642\u9593\u306e\u75c7\u72b6\u304c\u3001\u3044\u3061\u3070\u3093\u300c\u305f\u3044\u3057\u305f\u3053\u3068\u306a\u3044\u300d\u3068\u89e3\u91c8\u3055\u308c\u3084\u3059\u3044\u75c7\u72b6\u3068\u4e00\u81f4\u3057\u3066\u3044\u308b\u3002<\/p>\n<p><strong>\u3053\u308c\u304c\u3001\u809d\u81d3\u304c\u300c\u9759\u304b\u306b\u58ca\u308c\u308b\u300d\u3068\u3044\u3046\u3053\u3068\u306e\u5b9f\u4f53\u3067\u3059\u3002<\/strong><\/p>\n<p>\u6d3e\u624b\u306a\u8b66\u544a\u30b5\u30a4\u30f3\u306f\u51fa\u307e\u305b\u3093\u3002\u51fa\u308b\u3053\u308d\u306b\u306f\u3001\u9078\u629e\u80a2\u304c\u6e1b\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3060\u304b\u3089\u3053\u305d\u3001<strong>\u300c\u85ac\u3092\u98f2\u307f\u3059\u304e\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u300d\u3068\u601d\u3063\u305f\u3068\u304d\u306f\u3001\u75c7\u72b6\u304c\u8efd\u304f\u3066\u3082\u3001\u3042\u308b\u3044\u306f\u7121\u75c7\u72b6\u3067\u3082\u3001\u81ea\u5df1\u5224\u65ad\u3067\u69d8\u5b50\u3092\u898b\u306a\u3044\u3067\u304f\u3060\u3055\u3044\u3002<\/strong> \u533b\u7642\u6a5f\u95a2\u304b\u4e2d\u6bd2\u76f8\u8ac7\u306e\u7a93\u53e3\u306b\u9023\u7d61\u3057\u3066\u304f\u3060\u3055\u3044\u3002\u65e5\u672c\u4e2d\u6bd2\u60c5\u5831\u30bb\u30f3\u30bf\u30fc\u304c\u904b\u55b6\u3059\u308b\u300c\u4e2d\u6bd2110\u756a\u300d\u3068\u3044\u3046\u76f8\u8ac7\u7a93\u53e3\u304c\u3042\u308a\u307e\u3059\u304c\u3001<strong>\u96fb\u8a71\u756a\u53f7\u306f\u5909\u308f\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u3001\u5fc5\u305a\u516c\u5f0f\u30b5\u30a4\u30c8\u3067\u6700\u65b0\u306e\u3082\u306e\u3092\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044<\/strong>\uff08\u672c\u8a18\u4e8b\u3067\u306f\u756a\u53f7\u3092\u8a18\u8f09\u3057\u307e\u305b\u3093\uff09\u3002<\/p>\n<h2>\u3067\u306f\u3001NSAIDs \u306b\u66ff\u3048\u308c\u3070\u5b89\u5168\u306a\u306e\u304b<\/h2>\n<p>\u300c\u308f\u304b\u308a\u307e\u3057\u305f\u3001\u3067\u306f\u30a4\u30d6\u30d7\u30ed\u30d5\u30a7\u30f3\u306e\u307b\u3046\u306b\u3057\u307e\u3059\u300d\u3002<\/p>\n<p>\u79c1\u3082\u6700\u521d\u306f\u305d\u3046\u8003\u3048\u307e\u3057\u305f\u3002\u305f\u3060\u3001\u305d\u3061\u3089\u306b\u3082\u9003\u3052\u9053\u306f\u306a\u3044\u306e\u3067\u3059\u3002<\/p>\n<p>\u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u306e\u8cc7\u6599\u304b\u3089\u3001NSAIDs \u306b\u3088\u308b\u6d88\u5316\u7ba1\u969c\u5bb3\u306e\u983b\u5ea6\u3092\u6319\u3052\u307e\u3059\u3002<\/p>\n<ul>\n<li>\u9577\u671f\u670d\u7528\u8005\u306e<strong>\u80c3\u6f70\u760d\u767a\u751f\u7387\uff1a15.5\u301c30%<\/strong><\/li>\n<li>\u5341\u4e8c\u6307\u8178\u6f70\u760d\u767a\u751f\u7387\uff1a1.9\u301c4.9%<\/li>\n<li>NSAIDs \u670d\u7528\u60a3\u8005\u306e <strong>1.4%<\/strong> \u306b\u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840<\/li>\n<li>\u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u306e\u30ea\u30b9\u30af\uff1aNSAIDs \u670d\u7528\u8005\u3067<strong>\u30aa\u30c3\u30ba\u6bd4 6.1<\/strong><\/li>\n<li>\u305d\u3057\u3066\u3001<strong>\u6f70\u760d\u306e 42% \u306f\u7121\u75c7\u72b6<\/strong><\/li>\n<\/ul>\n<p>\u6700\u5f8c\u306e\u4e00\u884c\u304c\u3001\u3044\u3061\u3070\u3093\u91cd\u3044\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u540c\u30bb\u30f3\u30bf\u30fc\u306f\u3001\u6f70\u760d\u306f\u8179\u75db\u306b\u4e4f\u3057\u304f\u3001<strong>\u8ca7\u8840\u306e\u9032\u884c\u3084\u5410\u8840\u30fb\u4e0b\u8840\u3068\u3044\u3063\u305f\u51fa\u8840\u75c7\u72b6\u3067\u521d\u3081\u3066\u767a\u75c7\u304c\u5224\u660e\u3059\u308b\u3053\u3068\u304c\u591a\u3044<\/strong>\u3068\u3057\u3066\u3044\u307e\u3059\u3002\u3053\u3053\u3067\u3082\u300c\u9759\u304b\u306b\u9032\u3080\u300d\u306e\u3067\u3059\u306d\u3002<\/p>\n<p>\u305d\u3057\u3066\u98f2\u9152\u5f8c\u306e\u80c3\u306f\u3001\u3059\u3067\u306b\u6761\u4ef6\u304c\u60aa\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002\u4e00\u6a4b\u5927\u5b66\u4fdd\u5065\u30bb\u30f3\u30bf\u30fc\u306f\u300c\u80c3\u7c98\u819c\u306b\u9ad8\u6fc3\u5ea6\u306e\u30a2\u30eb\u30b3\u30fc\u30eb\u304c\u76f4\u63a5\u306b\u63a5\u89e6\u3059\u308b\u3068\u80c3\u7c98\u819c\u3092\u50b7\u5bb3\u3059\u308b\u300d\u3068\u3057\u3066\u304a\u308a\u3001\u4e45\u91cc\u6d5c\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u3082\u4e8c\u65e5\u9154\u3044\u306e\u6a5f\u5e8f\u305d\u306e\u3082\u306e\u306b\u80c3\u7c98\u819c\u306e\u30c0\u30e1\u30fc\u30b8\u3092\u542b\u3081\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u539a\u751f\u52b4\u50cd\u7701\u306e\u98f2\u9152\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3082\u3001\u907f\u3051\u308b\u3079\u304d\u98f2\u307f\u65b9\u3068\u3057\u3066\u300c\u75c5\u6c17\u7642\u990a\u4e2d\u30fb<strong>\u670d\u85ac\u5f8c\u306e\u98f2\u9152<\/strong>\u300d\u3092\u660e\u793a\u3057\u3066\u3044\u307e\u3059\u3002\u56fd\u304c\u660e\u6587\u3067\u793a\u3057\u3066\u3044\u308b\u3001\u6570\u5c11\u306a\u3044\u76f4\u63a5\u7684\u306a\u6ce8\u610f\u3067\u3059\u3002<\/p>\n<p>\u3072\u3068\u3064\u3001\u6b63\u76f4\u306b\u66f8\u3044\u3066\u304a\u304d\u305f\u3044\u3053\u3068\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u300c\u98f2\u9152\u304c NSAIDs \u306e\u6f70\u760d\u30fb\u51fa\u8840\u30ea\u30b9\u30af\u3092\u4f55\u500d\u306b\u3059\u308b\u304b\u300d\u3068\u3044\u3046\u5b9a\u91cf\u7684\u306a\u6570\u5024\u306f\u3001\u65e5\u672c\u306e\u516c\u7684\u306a\u4e00\u6b21\u8cc7\u6599\u3067\u306f\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/strong> \u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u304c\u6319\u3052\u308b\u5371\u967a\u56e0\u5b50\u8868\uff08\u6f70\u760d\u306e\u65e2\u5f80\u3001\u9ad8\u7528\u91cf\u3084\u8907\u6570 NSAIDs \u306e\u4f75\u7528\u3001\u4f4e\u7528\u91cf\u30a2\u30b9\u30d4\u30ea\u30f3\u306e\u4f75\u7528\u3001\u9ad8\u9f62\u8005\u3001\u30d4\u30ed\u30ea\u83cc\u611f\u67d3\u3001\u30b9\u30c6\u30ed\u30a4\u30c9\u4f75\u7528\uff09\u306b\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u306f\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3002\u3067\u3059\u306e\u3067\u500d\u7387\u306f\u66f8\u304d\u307e\u305b\u3093\u3002<\/p>\n<p>\u66f8\u3051\u308b\u306e\u306f\u3001\u6a5f\u5e8f\u306e\u8a71\u307e\u3067\u3067\u3059\u3002<strong>\u98f2\u9152\u3067\u80c3\u7c98\u819c\u306f\u3059\u3067\u306b\u76f4\u63a5\u523a\u6fc0\u3092\u53d7\u3051\u3066\u3044\u308b\u3002NSAIDs \u306f\u80c3\u7c98\u819c\u306e\u9632\u5fa1\u6a5f\u69cb\u3092\u5f31\u3081\u308b\u3002\u3053\u306e2\u3064\u304c\u91cd\u306a\u308b\u72b6\u6cc1\u306f\u907f\u3051\u305f\u3044\u3002<\/strong><\/p>\n<p>\u7d50\u8ad6\u3068\u3057\u3066\u3001\u69cb\u56f3\u306f\u3053\u3046\u306a\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306f\u809d\u81d3\u5074\u3002NSAIDs \u306f\u80c3\u30fb\u6d88\u5316\u7ba1\u5074\u3002\u98f2\u9152\u5f8c\u306f\u3069\u3061\u3089\u306e\u81d3\u5668\u306b\u3082\u8ca0\u8377\u304c\u304b\u304b\u3063\u3066\u3044\u308b\u3002\u300c\u3053\u3061\u3089\u306a\u3089\u5b89\u5168\u300d\u3068\u3044\u3046\u9003\u3052\u9053\u306f\u3001\u5b58\u5728\u3057\u307e\u305b\u3093\u3002<\/strong><\/p>\n<p>[\u5185\u90e8\u30ea\u30f3\u30af: \u95a2\u9023\u8a18\u4e8b &#8211; \u5e02\u8ca9\u306e\u89e3\u71b1\u93ae\u75db\u85ac\u3092\u9078\u3076\u3068\u304d\u306b\u78ba\u8a8d\u3057\u305f\u3044\u3053\u3068]<\/p>\n<h2>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u8acb\u6c42\u66f8\u306f\u3001\u7fcc\u671d\u3067\u306f\u306a\u304f\u6570\u5341\u5e74\u5f8c\u306b\u5c4a\u304f<\/h2>\n<p>\u3053\u3053\u3067\u8a71\u306e\u5411\u304d\u3092\u5909\u3048\u307e\u3059\u3002<\/p>\n<p>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306f\u3001\u7fcc\u671d\u306e\u982d\u75db\u306e\u72af\u4eba\u3068\u3057\u3066\u306f<strong>\u904e\u5927\u8a55\u4fa1<\/strong>\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002\u524d\u534a\u3067\u898b\u305f\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n<p>\u3068\u3053\u308d\u304c\u3001\u307e\u3063\u305f\u304f\u5225\u306e\u6642\u9593\u8ef8\u3067\u306f\u3001\u306f\u308b\u304b\u306b\u91cd\u3044\u554f\u984c\u3092\u62b1\u3048\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n<h3>\u65e5\u672c\u4eba\u306e\u7d0440%\u3001\u305d\u3057\u3066\u300c\u30b3\u30c3\u30d71\u676f\u3067\u8d64\u304f\u306a\u308b\u306a\u3089\u7d049\u5272\u300d<\/h3>\n<p>\u539a\u751f\u52b4\u50cd\u7701 e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u306b\u3088\u308c\u3070\u3001<strong>\u65e5\u672c\u4eba\u306e\u7d0440%\u306f ALDH2\uff08\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u5206\u89e3\u3059\u308b\u9175\u7d20\uff09\u306e\u50cd\u304d\u304c\u5f31\u3044<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001\u907a\u4f1d\u5b50\u691c\u67fb\u3092\u3057\u306a\u304f\u3066\u3082\u81ea\u5df1\u5224\u5b9a\u3067\u304d\u308b\u3001\u5b9f\u7528\u6027\u306e\u9ad8\u3044\u6307\u6a19\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u300c\u30b3\u30c3\u30d71\u676f\u306e\u30d3\u30fc\u30eb\u3067\u9854\u304c\u8d64\u304f\u306a\u308b\u4f53\u8cea\u300d\u306e\u4eba\u306f\u3001\u7d049\u5272\u306e\u78ba\u7387\u3067 ALDH2 \u306e\u50cd\u304d\u304c\u5f31\u3044\u3068\u5224\u5b9a\u3055\u308c\u308b\u3002<\/strong><\/p>\n<p>\u5fc3\u5f53\u305f\u308a\u306e\u3042\u308b\u65b9\u3082\u591a\u3044\u306e\u3067\u306f\u306a\u3044\u3067\u3057\u3087\u3046\u304b\u3002\u79c1\u3082\u3001\u98f2\u307f\u4f1a\u306e\u5199\u771f\u3067\u81ea\u5206\u306e\u9854\u8272\u3092\u78ba\u8a8d\u3057\u305f\u304f\u3061\u3067\u3059\u3002<\/p>\n<p>\u5730\u57df\u5dee\u3082\u3042\u308a\u307e\u3059\u3002e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u306b\u3088\u308c\u3070\u3001\u6b20\u640d\u578b\u306e\u5272\u5408\u306f\u6c96\u7e04\u30fb\u4e5d\u5dde\u5357\u90e8\u30fb\u6771\u5317\u306730%\u53f0\u4ee5\u4e0b\u3001\u4e5d\u5dde\u5317\u90e8\u30fb\u4eac\u90fd\u30fb\u5927\u962a\u30fb\u611b\u77e5\u306750%\u524d\u5f8c\u3002\u30db\u30e2\u6b20\u640d\u578b\u306f\u300c\u9152\u304c\u98f2\u3081\u306a\u3044\u4e0b\u6238\u306e\u4f53\u8cea\u300d\u3067\u3001\u30d8\u30c6\u30ed\u6b20\u640d\u578b\u3067\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\uff08\u9854\u9762\u7d05\u6f6e\u30fb\u52d5\u60b8\u306a\u3069\uff09\u304c\u8d77\u3053\u308a\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u30d8\u30c6\u30ed\u578b\u3068\u30db\u30e2\u578b\u306e\u6b63\u78ba\u306a\u5185\u8a33\uff08%\uff09\u306b\u3064\u3044\u3066\u306f\u3001\u4eca\u56de\u306e\u8abf\u67fb\u3067\u516c\u7684\u306a\u4e00\u6b21\u8cc7\u6599\u307e\u3067\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u305d\u3053\u306f\u65ad\u5b9a\u3057\u307e\u305b\u3093\u3002<\/p>\n<p><img decoding=\"async\" alt=\"\u65e5\u672c\u4eba\u306e\u7d0440%\u304cALDH2\u306e\u50cd\u304d\u304c\u5f31\u3044\u3053\u3068\u3092\u793a\u3059\u5186\u30b0\u30e9\u30d5\u3068\u3001\u30b3\u30c3\u30d71\u676f\u306e\u30d3\u30fc\u30eb\u3067\u9854\u304c\u8d64\u304f\u306a\u308b\u4eba\u306f\u7d049\u5272\u304c\u8a72\u5f53\u3059\u308b\u3068\u3044\u3046\u81ea\u5df1\u5224\u5b9a\u306e\u76ee\u5b89\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-6-7.png\" \/><\/p>\n<h3>\u30a8\u30bf\u30ce\u30fc\u30eb\u3082\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3082\u3001\u767a\u304c\u3093\u6027\u7269\u8cea\u3067\u3059<\/h3>\n<p>\u540c\u3058\u304f e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u304c\u3093\u300d\u304b\u3089\u3002<\/p>\n<p><strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u98f2\u6599\u4e2d\u306e\u30a8\u30bf\u30ce\u30fc\u30eb\u3068\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306f\u3001\u4e21\u8005\u306b\u767a\u304c\u3093\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/strong><\/p>\n<p>WHO \u304c\u95a2\u9023\u3092\u8a8d\u5b9a\u3057\u3066\u3044\u308b\u90e8\u4f4d\u306f\u3001\u982d\u9838\u90e8\uff08\u53e3\u8154\u30fb\u54bd\u982d\u30fb\u5589\u982d\uff09\u304c\u3093\u3001<strong>\u98df\u9053\u304c\u3093\uff08\u6241\u5e73\u4e0a\u76ae\u304c\u3093\uff09<\/strong>\u3001\u809d\u81d3\u304c\u3093\u3001\u5927\u8178\u304c\u3093\u3001\u5973\u6027\u306e\u4e73\u304c\u3093\u3002\u80c3\u304c\u3093\u3082 WCRF \u304c2018\u5e74\u306b\u8a8d\u5b9a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066\u6c7a\u5b9a\u7684\u306a\u306e\u304c\u3001\u6b21\u306e\u4e00\u6587\u3067\u3059\u3002<\/p>\n<p><strong>ALDH2 \u306e\u50cd\u304d\u304c\u5f31\u3044\u4f53\u8cea\u3067\u306f\u3001\u98df\u9053\u304c\u3093\u30fb\u982d\u9838\u90e8\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u7279\u306b\u9ad8\u307e\u308b\u3002<\/strong><\/p>\n<p>\u7d14\u30a2\u30eb\u30b3\u30fc\u30eb\u91cf\u3068\u306e\u95a2\u4fc2\u3082\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4e73\u304c\u3093\u306f10g \u5897\u3048\u308b\u3054\u3068\u306b\u30ea\u30b9\u30af\u304c 7.1% \u5897\u52a0\u3002\u5927\u8178\u304c\u3093\u306f\u30a8\u30bf\u30ce\u30fc\u30eb50g\u3067\u7d041.4\u500d\u3002\u80c3\u304c\u3093\u306f23g\u4ee5\u4e0a\u3067\u4e0a\u6607\u3057\u300192g\u4ee5\u4e0a\u3067\u7d0430%\u4e0a\u6607\u3002\u809d\u81d3\u304c\u3093\u306f60g\u4ee5\u4e0a\u30672\u500d\u4ee5\u4e0a\u306e\u983b\u5ea6\u3002<\/p>\n<p>2024\u5e74\u306b\u306f\u3001\u65e5\u672c\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u5927\u898f\u6a21\u306a\u30b2\u30ce\u30e0\u7814\u7a76\u3082\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002\u611b\u77e5\u770c\u304c\u3093\u30bb\u30f3\u30bf\u30fc\u3068\u540d\u53e4\u5c4b\u5927\u5b66\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c<strong>\u65e5\u672c\u4eba17\u4e075,672\u4eba<\/strong>\u306e\u30b2\u30ce\u30e0\u60c5\u5831\u3068\u98f2\u9152\u884c\u52d5\u3092\u89e3\u6790\u3057\u30012024\u5e745\u6708\u306b\u300eScience Advances\u300f\u306b\u63b2\u8f09\u3057\u305f\u3082\u306e\u3067\u3059\u3002ALDH2 rs671 \u306e\u907a\u4f1d\u578b\u5225\u306b\u5c64\u5225\u5316\u3057\u305f\u89e3\u6790\u3067\u3001GG\u578b\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3092\u4ee3\u8b1d\u3067\u304d\u98f2\u9152\u50be\u5411\u304c\u5f37\u3044\u3001GA\u578b\u306f\u5e45\u5e83\u3044\u98f2\u9152\u30d1\u30bf\u30fc\u30f3\u3001AA\u578b\u306f\u307b\u307c\u98f2\u9152\u3057\u306a\u3044\u3001\u3068\u3044\u3046\u533a\u5206\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u3053\u306e\u7814\u7a76\u306e\u89e3\u8aac\uff08\u65e5\u672c\u30b9\u30dd\u30fc\u30c4\u6804\u990a\u5354\u4f1a SNDJ\uff09\u306b\u3088\u308c\u3070\u3001<strong>ADH1B rs1229984 \u306b C \u5869\u57fa\u3092\u6301\u3064 GA\u578b\u306e\u4eba\u306f\u3001\u98df\u9053\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c 3.77\u500d<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u306a\u304a\u3001\u691c\u7d22\u3059\u308b\u3068\u3053\u308c\u3088\u308a\u306f\u308b\u304b\u306b\u5927\u304d\u3044\u500d\u7387\u3092\u6319\u3052\u308b\u8a18\u4e8b\u3082\u51fa\u3066\u304d\u307e\u3059\u304c\u3001<strong>\u4e00\u6b21\u6587\u732e\u3092\u78ba\u8a8d\u3067\u304d\u306a\u304b\u3063\u305f\u305f\u3081\u3001\u3053\u306e\u8a18\u4e8b\u3067\u306f\u63a1\u7528\u3057\u307e\u305b\u3093\u3002<\/strong><\/p>\n<h3>\u8acb\u6c42\u66f8\u306e\u8a71\u3092\u3057\u307e\u3059<\/h3>\n<p>\u8aad\u8005\u306e\u65b9\u304c\u3053\u306e\u8a18\u4e8b\u3092\u958b\u3044\u305f\u52d5\u6a5f\u306f\u3001\u305f\u3076\u3093\u300c\u4eca\u671d\u306e\u982d\u75db\u3092\u3069\u3046\u3059\u308b\u304b\u300d\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u79c1\u3082\u305d\u3046\u3067\u3057\u305f\u3002<\/p>\n<p>\u3067\u3082\u3001\u8cc7\u6599\u3092\u4e26\u3079\u7d42\u3048\u305f\u3068\u304d\u306b\u6b8b\u3063\u305f\u306e\u306f\u3001\u3053\u3046\u3044\u3046\u611f\u899a\u3067\u3057\u305f\u3002<\/p>\n<p><strong>\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306f\u3001\u7fcc\u671d\u306e\u982d\u75db\u306e\u8acb\u6c42\u66f8\u3092\u9001\u3063\u3066\u304d\u307e\u305b\u3093\u3002\u6570\u5341\u5e74\u5f8c\u306b\u9001\u3063\u3066\u304d\u307e\u3059\u3002<\/strong><\/p>\n<p>\u9854\u304c\u8d64\u304f\u306a\u308b\u4f53\u8cea\u306e\u65b9\u306b\u3068\u3063\u3066\u3001\u98f2\u9152\u4e2d\u301c\u76f4\u5f8c\u306b\u4f53\u5185\u3067\u9ad8\u6fc3\u5ea6\u306b\u306a\u308b\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u672c\u5f53\u306e\u554f\u984c\u306f\u3001\u7fcc\u65e5\u306e\u4e0d\u5feb\u611f\u3067\u306f\u306a\u304f\u3001\u98df\u9053\u304c\u3093\u30fb\u982d\u9838\u90e8\u304c\u3093\u3068\u3044\u3046\u9577\u3044\u6642\u9593\u8ef8\u306e\u307b\u3046\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u4eca\u671d\u306e\u982d\u75db\u306f\u3001\u3044\u305a\u308c\u6d88\u3048\u307e\u3059\u3002\u6d88\u3048\u306a\u3044\u306e\u306f\u3001\u7a4d\u307f\u91cd\u306d\u306e\u307b\u3046\u306a\u306e\u3067\u3059\u306d\u3002<\/p>\n<h2>\u300c\u52b9\u304f\u300d\u3068\u8a00\u308f\u308c\u308b\u3082\u306e\u306e\u6839\u62e0\u3092\u78ba\u304b\u3081\u308b<\/h2>\n<p>\u3067\u306f\u3001\u85ac\u4ee5\u5916\u306e\u5b9a\u756a\u306f\u3069\u3046\u306a\u306e\u304b\u3002\u3053\u3053\u3082\u6b63\u76f4\u306b\u66f8\u304d\u307e\u3059\u3002<\/p>\n<h3>\u524d\u63d0 \u2014 \u4e8c\u65e5\u9154\u3044\u5bfe\u7b56\u306b\u78ba\u7acb\u3057\u305f\u6839\u62e0\u306f\u3001\u307b\u307c\u3042\u308a\u307e\u305b\u3093<\/h3>\n<p>\u30b7\u30b9\u30c6\u30de\u30c6\u30a3\u30c3\u30af\u30ec\u30d3\u30e5\u30fc\u304c2\u4ef6\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>\u2460 Pittler \u3089\u3001BMJ 2005<\/strong> \u2014 \u30e9\u30f3\u30c0\u30e0\u5316\u6bd4\u8f03\u8a66\u9a138\u4ef6\u3092\u7d44\u307f\u5165\u308c\u3002\u30d7\u30ed\u30d7\u30e9\u30ce\u30ed\u30fc\u30eb\u3001\u30c8\u30ed\u30d4\u30bb\u30c8\u30ed\u30f3\u3001\u30c8\u30eb\u30d5\u30a7\u30ca\u30e0\u9178\u3001\u679c\u7cd6\u307e\u305f\u306f\u30d6\u30c9\u30a6\u7cd6\u3001\u30dc\u30e9\u30b4\u3001\u30a2\u30fc\u30c6\u30a3\u30c1\u30e7\u30fc\u30af\u3001\u30a6\u30c1\u30ef\u30b5\u30dc\u30c6\u30f3\u3001\u9175\u6bcd\u30d9\u30fc\u30b9\u88fd\u5264\u3092\u691c\u8a3c\u3002\u7d50\u8ad6\u306f\u300c<strong>\u5f93\u6765\u578b\u30fb\u88dc\u5b8c\u4ee3\u66ff\u7642\u6cd5\u306e\u3044\u305a\u308c\u306b\u3064\u3044\u3066\u3082\u3001\u4e8c\u65e5\u9154\u3044\u306e\u4e88\u9632\u307e\u305f\u306f\u6cbb\u7642\u306b\u6709\u52b9\u3067\u3042\u308b\u3053\u3068\u3092\u793a\u3059\u8aac\u5f97\u529b\u3042\u308b\u8a3c\u62e0\u306f\u5b58\u5728\u3057\u306a\u3044<\/strong>\u300d\u3002\u63a8\u5968\u306f\u300c<strong>\u6700\u3082\u52b9\u679c\u7684\u306a\u306e\u306f\u65ad\u9152\u307e\u305f\u306f\u7bc0\u9152<\/strong>\u300d\u3067\u3057\u305f\u3002\u8457\u8005\u306f\u3001\u5404\u4ecb\u5165\u306b\u3064\u3044\u3066\u5358\u4e00\u306e RCT \u3057\u304b\u5b58\u5728\u305b\u305a\u3001\u591a\u304f\u306f\u5c0f\u898f\u6a21\u3067\u3001\u3059\u3079\u3066\u691c\u8a3c\u3055\u308c\u3066\u3044\u306a\u3044\u75c7\u72b6\u30b9\u30b3\u30a2\u3092\u4f7f\u7528\u3057\u3066\u3044\u305f\u3068\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>\u2461 Roberts \u3089\u3001Addiction 2022<\/strong> \u2014 \u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u30e9\u30f3\u30c0\u30e0\u5316\u8a66\u9a1321\u4ef6\u3092\u8a55\u4fa1\u3002\u30af\u30ed\u30fc\u30d6\u62bd\u51fa\u7269\u3001\u7d05\u53c2\u3001\u97d3\u56fd\u68a8\u30b8\u30e5\u30fc\u30b9\u3001\u30af\u30eb\u30af\u30df\u30f3\u3001\u30d7\u30ed\u30d0\u30a4\u30aa\u30c6\u30a3\u30af\u30b9\u3001L-\u30b7\u30b9\u30c6\u30a4\u30f3\u3001NAC\u3001\u30a2\u30fc\u30c6\u30a3\u30c1\u30e7\u30fc\u30af\u62bd\u51fa\u7269\u3001\u30a6\u30c1\u30ef\u30b5\u30dc\u30c6\u30f3\u307b\u304b\u8a0821\u7a2e\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u8cea\u306f<strong>\u3059\u3079\u3066 very low<\/strong>\u3002<strong>\u540c\u3058\u30ec\u30e1\u30c7\u30a3\u3092\u6271\u3063\u305f\u7814\u7a76\u304c2\u3064\u3068\u3057\u3066\u306a\u304f\u3001\u72ec\u7acb\u3057\u305f\u518d\u73fe\u7d50\u679c\u306f\u30bc\u30ed<\/strong>\u3067\u3057\u305f\u3002\u6709\u52b9\u3068\u8a3c\u660e\u3055\u308c\u305f\u3082\u306e\u306f\u3001\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u3053\u306e\u30ec\u30d3\u30e5\u30fc\u306f\u3001\u3082\u3046\u3072\u3068\u3064\u91cd\u8981\u306a\u3053\u3068\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3084\u30a2\u30b9\u30d4\u30ea\u30f3\u3068\u3044\u3063\u305f\u4e00\u822c\u7684\u306a\u93ae\u75db\u85ac\u306b\u3064\u3044\u3066\u3082\u3001\u4e8c\u65e5\u9154\u3044\u306b\u5bfe\u3059\u308b\u53b3\u5bc6\u306a\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u306b\u3088\u308b\u8a55\u4fa1\u306f\u884c\u308f\u308c\u3066\u3044\u306a\u3044\u3002<\/strong><\/p>\n<p>\u3064\u307e\u308a\u300c\u52b9\u304f\u304b\u3069\u3046\u304b\u3001\u305d\u3082\u305d\u3082\u771f\u9762\u76ee\u306b\u8abf\u3079\u3089\u308c\u3066\u3044\u306a\u3044\u300d\u306e\u3067\u3059\u306d\u3002<\/p>\n<h3>\u306f\u3061\u307f\u3064\u6e6f\u30fb\u7cd6\u5206\u306b\u3064\u3044\u3066<\/h3>\n<p>Ylikahri 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1976\uff09\u306f\u3001<strong>\u679c\u7cd6\u3082\u30d6\u30c9\u30a6\u7cd6\u3082\u3001\u9169\u914a\u306e\u5f37\u3055\u306b\u3082\u4e8c\u65e5\u9154\u3044\u306e\u5f37\u3055\u306b\u3082\u6709\u610f\u306a\u52b9\u679c\u306f\u306a\u304f\u3001\u30a8\u30bf\u30ce\u30fc\u30eb\u6d88\u5931\u901f\u5ea6\u306b\u3082\u8840\u4e2d\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u6fc3\u5ea6\u306b\u3082\u6709\u610f\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u306a\u304b\u3063\u305f<\/strong>\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002\u30a8\u30bf\u30ce\u30fc\u30eb\u304c\u8a98\u767a\u3059\u308b\u4ee3\u8b1d\u306e\u4e71\u308c\u306f\u679c\u7cd6\u30fb\u30d6\u30c9\u30a6\u7cd6\u3068\u3082\u306b\u6709\u610f\u306b\u6291\u5236\u3057\u3001\u679c\u7cd6\u306e\u307b\u3046\u304c\u6709\u52b9\u3067\u306f\u3042\u308a\u307e\u3057\u305f\u304c\u3001\u4e8c\u65e5\u9154\u3044\u306e\u5f37\u3055\u305d\u306e\u3082\u306e\u306f\u52d5\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n<p>\u679c\u7cd6\u306e\u9759\u6ce8\u306b\u3064\u3044\u3066\u306f\u3001\u8840\u4e2d\u30a8\u30bf\u30ce\u30fc\u30eb\u6fc3\u5ea6\u306e\u4f4e\u4e0b\u901f\u5ea6\u3092\u308f\u305a\u304b\u306b\u6709\u610f\u306b\u5897\u52a0\u3055\u305b\u305f\u3068\u3059\u308b\u5bfe\u7167\u8a66\u9a13\uff08Lancet 1972\uff09\u304c\u3042\u308a\u307e\u3059\u304c\u3001<strong>\u7d4c\u53e3\u6442\u53d6\u3067\u306f\u5b9f\u7528\u7684\u306a\u610f\u5473\u306f\u306a\u3044<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u9759\u6ce8\u3068\u7d4c\u53e3\u3092\u6df7\u540c\u3057\u306a\u3044\u307b\u3046\u304c\u3044\u3044\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n<p>\u3067\u3059\u304b\u3089\u3001\u300c\u306f\u3061\u307f\u3064\u6e6f\u304c\u4e8c\u65e5\u9154\u3044\u3092\u6cbb\u3059\u300d\u306b\u306f\u6839\u62e0\u304c\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u305f\u3060\u3057\u3001\u982d\u3054\u306a\u3057\u306b\u5426\u5b9a\u3059\u308b\u5fc5\u8981\u3082\u306a\u3044\u3068\u601d\u3063\u3066\u3044\u307e\u3059\u3002\u4f4e\u8840\u7cd6\u304c\u4e8c\u65e5\u9154\u3044\u306e\u4e00\u56e0\u3067\u3042\u308b\u4ee5\u4e0a\u3001<strong>\u4f55\u304b\u3092\u98df\u3079\u3066\u8840\u7cd6\u3092\u623b\u3059\u3053\u3068\u81ea\u4f53\u306f\u7406\u306b\u304b\u306a\u3063\u3066\u3044\u308b<\/strong>\u304b\u3089\u3067\u3059\u3002\u305d\u308c\u306f\u300c\u306f\u3061\u307f\u3064\u306e\u7279\u5225\u306a\u52b9\u679c\u300d\u3067\u306f\u306a\u304f\u3001\u5358\u306b\u300c\u98df\u4e8b\u300d\u306e\u52b9\u679c\u306a\u306e\u3067\u3059\u306d\u3002<\/p>\n<h3>\u8c46\u3082\u3084\u3057\u30b9\u30fc\u30d7\u30fb\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u306b\u3064\u3044\u3066<\/h3>\n<p><strong>\u4eca\u56de\u306e\u8abf\u67fb\u3067\u306f\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u306e\u4e8c\u65e5\u9154\u3044\u3078\u306e\u52b9\u679c\u306b\u3064\u3044\u3066\u3001\u30d2\u30c8\u3067\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u6839\u62e0\u3092\u78ba\u8a8d\u3067\u304d\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/strong><\/p>\n<p>\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u304c\u975e\u5fc5\u9808\u30a2\u30df\u30ce\u9178\u3067\u3042\u308a\u3001\u4f53\u5185\u3067\u7a92\u7d20\u3084\u30a8\u30cd\u30eb\u30ae\u30fc\u306e\u4ee3\u8b1d\u306b\u95a2\u4fc2\u3057\u3001\u30a2\u30f3\u30e2\u30cb\u30a2\u306e\u89e3\u6bd2\u4f5c\u7528\u304c\u77e5\u3089\u308c\u3066\u3044\u308b\u3001\u3068\u3044\u3046\u4e00\u822c\u7684\u306a\u751f\u5316\u5b66\u306e\u8aac\u660e\u307e\u3067\u306f\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002\u305f\u3060\u3057\u305d\u308c\u306f\u300c\u4e8c\u65e5\u9154\u3044\u306b\u52b9\u304f\u300d\u3053\u3068\u306e\u8a3c\u660e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u5404\u7a2e\u98df\u54c1\u304c\u30a2\u30eb\u30b3\u30fc\u30eb\u5206\u89e3\u9175\u7d20\uff08ADH\u30fbALDH\uff09\u306e\u6d3b\u6027\u3092\u4fc3\u3059\u304b\u3092\u8abf\u3079\u305f\u5b9f\u9a13\u3067\u3082\u3001\u9175\u7d20\u6d3b\u6027\u306e\u5897\u52a0\u3092\u793a\u3057\u305f\u98df\u54c1\u306f\u307b\u3068\u3093\u3069\u306a\u304b\u3063\u305f\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002BMJ 2005\u30fbAddiction 2022 \u306e\u3069\u3061\u3089\u306e\u30ec\u30d3\u30e5\u30fc\u306b\u3082\u3001\u30a2\u30b9\u30d1\u30e9\u30ae\u30f3\u9178\u5358\u72ec\u306e\u4e8c\u65e5\u9154\u3044 RCT \u306f\u542b\u307e\u308c\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<p>\u3068\u306f\u3044\u3048\u3001\u6e29\u304b\u3044\u6c41\u7269\u3092\u98df\u3079\u308b\u3053\u3068\u81ea\u4f53\u3092\u5426\u5b9a\u3059\u308b\u7406\u7531\u3082\u3042\u308a\u307e\u305b\u3093\u3002\u6c34\u5206\u3068\u96fb\u89e3\u8cea\u3068\u98df\u4e8b\u3068\u3057\u3066\u306e\u5408\u7406\u6027\u306f\u3042\u308a\u307e\u3059\u304b\u3089\u3002\u300c\u52b9\u304f\u300d\u3068\u300c\u60aa\u304f\u306a\u3044\u300d\u3092\u5206\u3051\u3066\u8003\u3048\u308c\u3070\u8db3\u308a\u307e\u3059\u3002<\/p>\n<h3>\u6c34\u30fb\u30a4\u30aa\u30f3\u98f2\u6599\u306b\u3064\u3044\u3066 \u2014 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<strong>\u300c\u9577\u5e74\u306b\u308f\u305f\u308b\u98f2\u9152\u306e\u7fd2\u6163\u304c\u3042\u308b\u4eba\u300d\u3002<\/strong><\/p>\n<p>\u3064\u307e\u308a\u3001\u98f2\u307f\u3059\u304e\u305f\u7fcc\u671d\u306b\u809d\u81d3\u306e\u305f\u3081\u3092\u601d\u3063\u3066\u30a6\u30b3\u30f3\u306b\u624b\u3092\u4f38\u3070\u3059\u5c64\u304c\u3001\u305d\u306e\u307e\u307e\u30cf\u30a4\u30ea\u30b9\u30af\u7fa4\u3068\u3057\u3066\u540d\u6307\u3057\u3055\u308c\u3066\u3044\u308b\u308f\u3051\u3067\u3059\u306d\u3002<\/p>\n<p>\u6edd\u5ddd\u533b\u5e2b\u306e\u30b3\u30e1\u30f3\u30c8\u3082\u5f15\u3044\u3066\u304a\u304d\u307e\u3059\u3002\u300c\u4e00\u822c\u7528\u533b\u85ac\u54c1\u3084\u5065\u5eb7\u98df\u54c1\u306f\u3001\u30c9\u30e9\u30c3\u30b0\u30b9\u30c8\u30a2\u3084\u30a4\u30f3\u30bf\u30fc\u30cd\u30c3\u30c8\u3067\u5bb9\u6613\u306b\u8cfc\u5165\u30fb\u4f7f\u7528\u3067\u304d\u308b\u304c\u3001\u4f7f\u7528\u3059\u308b\u5834\u5408\u306f\u3001\u85ac\u7269\u6027\u809d\u969c\u5bb3\u306e\u3088\u3046\u306a\u526f\u4f5c\u7528\u304c\u8d77\u3053\u308b\u3053\u3068\u304c\u3042\u308b\u3068\u3044\u3046\u3053\u3068\u3092\u77e5\u3063\u3066\u307b\u3057\u3044\u300d\u3002<\/p>\n<p>\u88fd\u54c1\u540d\u3084\u30d6\u30e9\u30f3\u30c9\u540d\u3092\u6319\u3052\u308b\u3064\u3082\u308a\u306f\u3042\u308a\u307e\u305b\u3093\u3002<strong>\u300c\u30a6\u30b3\u30f3\u3092\u542b\u3080\u5065\u5eb7\u98df\u54c1\u300d\u3068\u3044\u3046\u4e00\u822c\u540d\u3067\u53d7\u3051\u53d6\u3063\u3066\u304f\u3060\u3055\u3044\u3002<\/strong><\/p>\n<p>\u306a\u304a\u3001\u3053\u306e 29\u4ef6\uff0825%\uff09\u3068\u3044\u3046\u5185\u8a33\u306f\u3001\u65e5\u672c\u809d\u81d3\u5b66\u4f1a\u306e\u5831\u544a\u3068\u3057\u3066\u8907\u6570\u306e\u5a92\u4f53\u304c\u5f15\u7528\u3057\u3066\u3044\u308b\u3082\u306e\u3067\u3059\u3002\u5b66\u4f1a\u306e\u4e00\u6b21\u8cc7\u6599\u305d\u306e\u3082\u306e\u306f\u4eca\u56de\u53d6\u5f97\u3067\u304d\u306a\u304b\u3063\u305f\u305f\u3081\u3001<strong>\u300c\u65e5\u672c\u809d\u81d3\u5b66\u4f1a\u306e\u5831\u544a\u306b\u3088\u308b\u3068\u300d\u3068\u3044\u3046\u7559\u4fdd\u3064\u304d\u306e\u6570\u5b57<\/strong>\u3068\u3057\u3066\u6271\u3044\u307e\u3059\u3002<\/p>\n<h2>\u6c57\u3092\u304b\u3051\u3070\u65e9\u304f\u629c\u3051\u308b\u306e\u304b \u2014 \u904b\u52d5\u3068\u5165\u6d74\u306b\u3064\u3044\u3066<\/h2>\n<p>\u300c\u30b5\u30a6\u30ca\u3067\u6d41\u3057\u3066\u304f\u308b\u300d\u300c\u4e00\u99c5\u6b69\u3044\u3066\u6c57\u3092\u304b\u304f\u300d\u3002\u3088\u304f\u805e\u304f\u8a71\u3067\u3059\u3002<\/p>\n<p>\u3053\u308c\u306f\u3001\u6210\u7acb\u3057\u307e\u305b\u3093\u3002<\/p>\n<p>\u524d\u7ae0\u306e\u3068\u304a\u308a\u3001\u5206\u89e3\u306e\u5927\u90e8\u5206\u306f\u809d\u81d3\u304c\u62c5\u3063\u3066\u304a\u308a\u3001\u6c57\u3084\u5c3f\u304b\u3089\u306e\u6392\u6cc4\u306f\u308f\u305a\u304b\u3067\u3059\u3002\u4ee3\u8b1d\u901f\u5ea6\u306f\u307b\u307c\u4e00\u5b9a\u3067\u3001\u5916\u304b\u3089\u52a0\u901f\u3059\u308b\u65b9\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n<p>\u305d\u308c\u3069\u3053\u308d\u304b\u3001<strong>\u539a\u751f\u52b4\u50cd\u7701\u306e\u300e\u5065\u5eb7\u306b\u914d\u616e\u3057\u305f\u98f2\u9152\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u300f\uff082024\u5e742\u670819\u65e5\u516c\u8868\uff09\u306f\u3001\u300c\u98f2\u9152\u4e2d\u30fb\u98f2\u9152\u5f8c\u306e\u904b\u52d5\u30fb\u5165\u6d74\u300d\u3092\u907f\u3051\u308b\u3079\u304d\u98f2\u307f\u65b9\u3068\u3057\u3066\u660e\u793a\u3057\u3066\u3044\u307e\u3059\u3002<\/strong> \u4e00\u6642\u591a\u91cf\u98f2\u9152\u3001\u4ed6\u4eba\u3078\u306e\u98f2\u9152\u5f37\u8981\u3001\u4e0d\u5b89\u3084\u4e0d\u7720\u306e\u89e3\u6d88\u76ee\u7684\u306e\u98f2\u9152\u3001\u75c5\u6c17\u7642\u990a\u4e2d\u30fb\u670d\u85ac\u5f8c\u306e\u98f2\u9152\u3082\u540c\u69d8\u306b\u6319\u3052\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u98f2\u9152\u76f4\u5f8c\u306e\u5165\u6d74\u3084\u6fc0\u3057\u3044\u904b\u52d5\u306f\u3001\u5fc3\u81d3\u3084\u8840\u5727\u306b\u8ca0\u62c5\u3092\u304b\u3051\u3001\u4f53\u8abf\u4e0d\u826f\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002\u300c\u30c7\u30c8\u30c3\u30af\u30b9\u300d\u306e\u3064\u3082\u308a\u306e\u884c\u52d5\u304c\u3001\u907f\u3051\u308b\u3079\u304d\u884c\u52d5\u3068\u3057\u3066\u56fd\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306b\u8f09\u3063\u3066\u3044\u308b\u3002\u3053\u3053\u306f\u77e5\u3063\u3066\u304a\u3044\u3066\u640d\u304c\u306a\u3044\u3068\u3053\u308d\u3060\u3068\u601d\u3044\u307e\u3059\u3002<\/p>\n<p>\u540c\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u3067\u306f\u3001\u751f\u6d3b\u7fd2\u6163\u75c5\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u308b\u98f2\u9152\u91cf\u3068\u3057\u3066<strong>\u7537\u60271\u65e540g\u4ee5\u4e0a\u3001\u5973\u60271\u65e520g\u4ee5\u4e0a<\/strong>\u3068\u3044\u3046\u6570\u5024\u304c\u793a\u3055\u308c\u3066\u3044\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7d14\u30a2\u30eb\u30b3\u30fc\u30eb20g\u306f\u3001\u30d3\u30fc\u30eb500mL 1\u672c\u3001\u307e\u305f\u306f\u65e5\u672c\u91521\u5408\u306b\u76f8\u5f53\u3057\u307e\u3059\u3002<strong>\u305f\u3060\u3057\u3053\u306e40g\uff0f20g \u3068\u3044\u3046\u6570\u5024\u306f\u3001\u4eca\u56de\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u672c\u4f53\u306e PDF \u304b\u3089\u76f4\u63a5\u62bd\u51fa\u3067\u304d\u305a\u3001\u4e8c\u6b21\u60c5\u5831\u3092\u7d4c\u7531\u3057\u3066\u78ba\u8a8d\u3057\u305f\u3082\u306e\u3067\u3059\u3002<\/strong> \u6b63\u78ba\u306a\u8a18\u8f09\u306f\u539a\u751f\u52b4\u50cd\u7701\u306e\u30da\u30fc\u30b8\u3067\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2>\u85ac\u306b\u624b\u3092\u4f38\u3070\u3059\u524d\u306b\u3001\u3067\u304d\u308b\u3053\u3068<\/h2>\n<p>\u300c\u3042\u308c\u3082\u6839\u62e0\u304c\u306a\u3044\u3001\u3053\u308c\u3082\u5371\u306a\u3044\u300d\u3067\u7d42\u308f\u3089\u305b\u308b\u3068\u3001\u3044\u3061\u3070\u3093\u56f0\u308b\u306e\u306f\u8aad\u3093\u3067\u304f\u3060\u3055\u3063\u305f\u65b9\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u3067\u3059\u304b\u3089\u3001\u66f8\u3051\u308b\u3053\u3068\u3092\u66f8\u304d\u307e\u3059\u3002<\/p>\n<p><strong>\u5148\u306b\u65ad\u3063\u3066\u304a\u304d\u307e\u3059\u3002\u4e8c\u65e5\u9154\u3044\u3092\u300c\u6cbb\u3059\u300d\u65b9\u6cd5\u306f\u3001\u3053\u3053\u306b\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/strong> \u78ba\u5b9f\u306a\u306e\u306f\u6642\u9593\u3068\u3001\u7bc0\u9152\u30fb\u65ad\u9152\u3060\u3051\u3067\u3059\u3002\u305d\u308c\u3067\u3082\u3001\u6761\u4ef6\u3092\u60aa\u304f\u3057\u306a\u3044\u884c\u52d5\u306f\u3042\u308a\u307e\u3059\u3002<\/p>\n<ul>\n<li><strong>\u4f55\u304b\u98df\u3079\u308b<\/strong> \u2014 \u4f4e\u8840\u7cd6\u306f\u4e8c\u65e5\u9154\u3044\u306e\u4e00\u56e0\u3067\u3059\u3002\u7d76\u98df\u306e\u307e\u307e\u93ae\u75db\u85ac\u306b\u624b\u3092\u4f38\u3070\u3059\u306e\u306f\u3001\u30b0\u30eb\u30bf\u30c1\u30aa\u30f3\u306e\u5074\u304b\u3089\u898b\u3066\u3044\u3061\u3070\u3093\u6761\u4ef6\u304c\u60aa\u3044\u72b6\u614b\u3067\u3059\u3002\u304a\u304b\u3086\u3067\u3082\u6c41\u7269\u3067\u3082\u3001\u80c3\u304c\u53d7\u3051\u3064\u3051\u308b\u3082\u306e\u3092<\/li>\n<li><strong>\u6c34\u5206\u3092\u6442\u308b<\/strong> \u2014 \u76ee\u7684\u306f\u300c\u65e9\u304f\u629c\u304f\u305f\u3081\u300d\u3067\u306f\u306a\u304f\u300c\u8131\u6c34\u3092\u88dc\u3046\u305f\u3081\u300d\u3002\u3053\u3053\u3092\u53d6\u308a\u9055\u3048\u306a\u3044\u3053\u3068<\/li>\n<li><strong>\u85ac\u7bb1\u3092\u958b\u3051\u308b\u524d\u306b\u3001\u6210\u5206\u8868\u793a\u3092\u898b\u308b<\/strong> \u2014 \u7dcf\u5408\u611f\u5192\u85ac\u3084\u9f3b\u708e\u85ac\u3068\u91cd\u306a\u3089\u306a\u3044\u304b\u3092\u78ba\u8a8d\u3059\u308b<\/li>\n<li><strong>\u85ac\u5264\u5e2b\u306b\u98f2\u9152\u7fd2\u6163\u3092\u4f1d\u3048\u308b<\/strong> \u2014 \u300c\u666e\u6bb5\u3088\u304f\u98f2\u307f\u307e\u3059\u300d\u3068\u8a00\u3048\u308b\u304b\u3069\u3046\u304b\u3067\u3001\u63d0\u6848\u306f\u5909\u308f\u308a\u307e\u3059<\/li>\n<li><strong>\u904b\u52d5\u3068\u5165\u6d74\u3092\u6025\u304c\u306a\u3044<\/strong> \u2014 \u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u907f\u3051\u308b\u3079\u304d\u98f2\u307f\u65b9\u306b\u6319\u3052\u3066\u3044\u307e\u3059<\/li>\n<li><strong>\u6642\u9593\u3092\u6e21\u3059<\/strong> \u2014 \u3044\u3061\u3070\u3093\u4e0d\u4fbf\u3067\u3001\u3044\u3061\u3070\u3093\u78ba\u5b9f\u306a\u65b9\u6cd5\u3067\u3059<\/li>\n<\/ul>\n<p>\u305d\u3057\u3066\u3001\u6b21\u306b\u98f2\u3080\u65e5\u306e\u305f\u3081\u306b\u3002<\/p>\n<p>\u539a\u751f\u52b4\u50cd\u7701\u306e\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u306f\u3001\u7d14\u30a2\u30eb\u30b3\u30fc\u30eb\u91cf\u306e\u8a08\u7b97\u5f0f\u3082\u793a\u3057\u3066\u3044\u307e\u3059\u3002<strong>\u6442\u53d6\u91cf\uff08mL\uff09\u00d7 \u30a2\u30eb\u30b3\u30fc\u30eb\u6fc3\u5ea6\uff08\u5ea6\u6570\u00f7100\uff09\u00d7 0.8<\/strong>\u3002\u81ea\u5206\u304c\u6628\u591c\u3069\u308c\u3060\u3051\u5165\u308c\u305f\u306e\u304b\u3092\u4e00\u5ea6\u3060\u3051\u8a08\u7b97\u3057\u3066\u307f\u308b\u3068\u3001\u7fcc\u671d\u306e\u666f\u8272\u304c\u5c11\u3057\u5909\u308f\u308a\u307e\u3059\u3002<\/p>\n<p>[\u5185\u90e8\u30ea\u30f3\u30af: \u95a2\u9023\u8a18\u4e8b &#8211; \u4f1a\u793e\u54e1\u306e\u8102\u80aa\u809d\u3068\u98f2\u307f\u4f1a\u3068\u306e\u4ed8\u304d\u5408\u3044\u65b9]<\/p>\n<h2>\u898b\u9003\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u7dca\u6025\u30b5\u30a4\u30f3<\/h2>\n<p>\u3053\u3053\u306f\u98db\u3070\u3055\u305a\u306b\u8aad\u3093\u3067\u3044\u305f\u3060\u304d\u305f\u3044\u90e8\u5206\u3067\u3059\u3002<\/p>\n<h3>\u9154\u3044\u3064\u3076\u308c\u305f\u4eba\u3092\u3001\u5bdd\u304b\u305b\u3066\u304a\u3044\u3066\u306f\u3044\u3051\u307e\u305b\u3093<\/h3>\n<p>\u6e08\u751f\u4f1a\u306e\u8cc7\u6599\u304b\u3089\u3002\u6025\u6027\u30a2\u30eb\u30b3\u30fc\u30eb\u4e2d\u6bd2\u306e\u91cd\u5ea6\u306e\u75c7\u72b6\u306b\u306f\u3001<strong>\u660f\u7761\u3001\u547c\u5438\u6291\u5236\u3001\u547c\u5438\u505c\u6b62\u3001\u4f4e\u4f53\u6e29<\/strong>\u304c\u6319\u3052\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066\u3001<strong>\u7d76\u5bfe\u306b\u3057\u3066\u306f\u3044\u3051\u306a\u3044\u3053\u3068<\/strong>\u3068\u3057\u3066\u3001\u3053\u3046\u660e\u8a18\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<blockquote>\n<p><strong>\u300c\u5614\u5410\u3057\u305f\u3082\u306e\u3067\u7a92\u606f\u3059\u308b\u5834\u5408\u304c\u3042\u308b\u306e\u3067\u3001\u6c7a\u3057\u3066\u4e00\u4eba\u306b\u3057\u3066\u653e\u7f6e\u3057\u3066\u306f\u3044\u3051\u307e\u305b\u3093\u300d<\/strong><\/p>\n<\/blockquote>\n<p><strong>\u3059\u3050\u306b119\u756a\u3059\u308b\u30b5\u30a4\u30f3<\/strong>\u306f\u6b21\u306e\u3068\u304a\u308a\u3067\u3059\u3002<\/p>\n<ul>\n<li><strong>\u547c\u3073\u304b\u3051\u306b\u5168\u304f\u53cd\u5fdc\u3057\u306a\u3044\uff0f\u547c\u3093\u3067\u3082\u8fd4\u4e8b\u3092\u3057\u306a\u3044<\/strong><\/li>\n<li><strong>\u547c\u5438\u304c\u304a\u304b\u3057\u3044<\/strong><\/li>\n<li><strong>\u4f53\u304c\u51b7\u305f\u3044<\/strong><\/li>\n<li><strong>\u75d9\u6523\u3057\u3066\u3044\u308b<\/strong><\/li>\n<\/ul>\n<p><strong>\u5f85\u3063\u3066\u3044\u308b\u3042\u3044\u3060\u306b\u3059\u308b\u3053\u3068<\/strong><\/p>\n<ul>\n<li><strong>\u56de\u5fa9\u4f53\u4f4d\u306b\u3059\u308b<\/strong> \u2014 \u4f53\u3092\u6a2a\u5411\u304d\u306b\u3057\u3001\u4e0b\u306e\u8155\u3092\u524d\u306b\u51fa\u3057\u3001\u4e0a\u306e\u819d\u3092\u66f2\u3052\u3066\u5b89\u5b9a\u3055\u305b\u308b\u3002\u4ef0\u5411\u3051\u306e\u307e\u307e\u3067\u306f\u5614\u5410\u7269\u304c\u6c17\u7ba1\u306b\u8a70\u307e\u308a\u3001\u7a92\u606f\u3059\u308b\u5371\u967a\u304c\u3042\u308a\u307e\u3059<\/li>\n<li><strong>\u4fdd\u6e29\u3059\u308b<\/strong> \u2014 \u6025\u6fc0\u306a\u4f53\u6e29\u4f4e\u4e0b\u304c\u307f\u3089\u308c\u308b\u3053\u3068\u304c\u3042\u308b\u305f\u3081\u6bdb\u5e03\u3092\u304b\u3051\u3001\u30d9\u30eb\u30c8\u306a\u3069\u4f53\u3092\u7de0\u3081\u4ed8\u3051\u3066\u3044\u308b\u3082\u306e\u306f\u7de9\u3081\u308b<\/li>\n<\/ul>\n<p><strong>\u3084\u3063\u3066\u306f\u3044\u3051\u306a\u3044\u5fdc\u6025\u624b\u5f53<\/strong><\/p>\n<ul>\n<li>\u7121\u7406\u306b\u5410\u304b\u305b\u308b<\/li>\n<li>\u7121\u7406\u306b\u7acb\u305f\u305b\u308b<\/li>\n<li>\u7121\u7406\u306b\u6c34\u3092\u98f2\u307e\u305b\u308b<\/li>\n<li>\u71b1\u3044\u98a8\u5442\u306b\u5165\u308c\u308b<\/li>\n<\/ul>\n<p>\u6771\u4eac\u6d88\u9632\u5e81\u306e\u8cc7\u6599\u306b\u3088\u308c\u3070\u3001\u6025\u6027\u30a2\u30eb\u30b3\u30fc\u30eb\u4e2d\u6bd2\u3067\u6551\u6025\u642c\u9001\u3055\u308c\u308b\u60a3\u8005\u306e <strong>47% \u304c\u3001\u672a\u6210\u5e74\u8005\u3092\u542b\u308020\u4ee3\u4ee5\u4e0b<\/strong>\u3067\u3059\u3002\u5c4b\u5916\u3067\u5bdd\u8fbc\u3081\u3070\u51cd\u6b7b\u306e\u30ea\u30b9\u30af\u3082\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3>\u53d7\u8a3a\u3059\u3079\u304d\u305d\u306e\u4ed6\u306e\u30b5\u30a4\u30f3<\/h3>\n<ul>\n<li><strong>\u5410\u8840\u30fb\u9ed2\u8272\u4fbf\uff08\u4e0b\u8840\uff09<\/strong> \u2014 \u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u306e\u30b5\u30a4\u30f3\u3067\u3059\u3002NSAIDs \u6f70\u760d\u306e42%\u306f\u8179\u75db\u306b\u4e4f\u3057\u304f\u3001\u51fa\u8840\u75c7\u72b6\u3067\u521d\u3081\u3066\u5224\u660e\u3059\u308b\u3053\u3068\u304c\u591a\u3044\u3068\u3055\u308c\u3066\u3044\u307e\u3059<\/li>\n<li><strong>\u9ec4\u75b8\uff08\u76ae\u819a\u3084\u767d\u76ee\u304c\u9ec4\u8272\u304f\u306a\u308b\uff09\u3001\u8910\u8272\u5c3f<\/strong> \u2014 \u809d\u969c\u5bb3\u306e\u30b5\u30a4\u30f3\u3067\u3059<\/li>\n<li><strong>\u6fc0\u3057\u3044\u8179\u75db\u3001\u7279\u306b\u53f3\u4e0a\u8179\u90e8\u306e\u75db\u307f<\/strong> \u2014 \u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u4e2d\u6bd2\u306e\u7b2cII\u671f\u306e\u5178\u578b\u75c7\u72b6\u3067\u3059<\/li>\n<li><strong>\u6301\u7d9a\u3059\u308b\u5026\u6020\u611f\u3001\u98df\u6b32\u4e0d\u632f\u3001\u767a\u71b1\u3001\u767a\u75b9<\/strong> \u2014 \u85ac\u7269\u6027\u809d\u969c\u5bb3\u306e\u75c7\u72b6\u3068\u3057\u3066\u6319\u3052\u3089\u308c\u3066\u3044\u307e\u3059<\/li>\n<li><strong>\u85ac\u3092\u98f2\u307f\u3059\u304e\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u601d\u3063\u305f\u3068\u304d<\/strong> \u2014 \u75c7\u72b6\u304c\u8efd\u304f\u3066\u3082\u3001\u7121\u75c7\u72b6\u3067\u3082\u3001\u6642\u9593\u304c\u7d4c\u3064\u307b\u3069\u6cbb\u7642\u306e\u9078\u629e\u80a2\u304c\u72ed\u307e\u308a\u307e\u3059<\/li>\n<\/ul>\n<p><img decoding=\"async\" alt=\"\u660e\u308b\u3044\u30aa\u30d5\u30a3\u30b9\u306e\u30ab\u30a6\u30f3\u30bf\u30fc\u8d8a\u3057\u306b\u3001\u30b3\u30fc\u30d2\u30fc\u3092\u624b\u306b\u7a4f\u3084\u304b\u306b\u8a71\u3059\u6771\u30a2\u30b8\u30a2\u7cfb\u306e\u7537\u60272\u4eba\" src=\"https:\/\/wewellinfo.com\/jp\/wp-content\/uploads\/2026\/08\/body-7-4.jpg\" \/><\/p>\n<p><em>Photo: RDNE Stock project \/ Pexels<\/em><\/p>\n<h2>\u305d\u308c\u3067\u3082\u3001\u623b\u308b\u6bb5\u968e\u304c\u3042\u308a\u307e\u3059<\/h2>\n<p>\u91cd\u3044\u8a71\u304c\u7d9a\u3044\u305f\u306e\u3067\u3001\u6700\u5f8c\u306b\u5e0c\u671b\u306e\u307b\u3046\u3092\u66f8\u304b\u305b\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<p>\u307e\u305a\u73fe\u72b6\u304b\u3089\u3002\u904e\u5ea6\u306e\u98f2\u9152\u3092\u3059\u308b\u4eba\u306e<strong>90%\u4ee5\u4e0a\u306b\u8102\u80aa\u306e\u84c4\u7a4d\uff08\u8102\u80aa\u809d\uff09\u304c\u307f\u3089\u308c\u308b<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\uff08MSD\u30de\u30cb\u30e5\u30a2\u30eb\u5bb6\u5ead\u7248\uff09\u3002\u809d\u708e\u60c5\u5831\u30bb\u30f3\u30bf\u30fc\u306b\u3088\u308c\u3070\u3001\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u969c\u5bb3\u306e\u8a3a\u65ad\u57fa\u6e96\u306f\u30011\u65e5\u306b\u7d14\u30a8\u30bf\u30ce\u30fc\u30eb\u63db\u7b97\u306760g\u4ee5\u4e0a\u306e\u98f2\u9152\u3092\u901a\u5e385\u5e74\u4ee5\u4e0a\u7d9a\u3051\u3066\u3044\u308b\u3053\u3068\u3002\u305f\u3060\u3057<strong>\u5973\u6027\u3084\u907a\u4f1d\u7684\u306b\u30a2\u30eb\u30b3\u30fc\u30eb\u8010\u6027\u304c\u4f4e\u3044\u4eba\u3067\u306f\u30011\u65e540g\u7a0b\u5ea6\u3067\u3082\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u969c\u5bb3\u3092\u8d77\u3053\u3057\u3046\u308b<\/strong>\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u305d\u3057\u3066\u65e5\u672c\u306e\u7279\u5fb4\u3068\u3057\u3066\u3001\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u708e\u306e\u708e\u75c7\u6240\u898b\u3084\u75c7\u72b6\u3084\u65e2\u5f80\u304c\u306a\u304f\u3001\u809d\u81d3\u306e\u7d44\u7e54\u5185\u306b<strong>\u7dda\u7dad\u5316\u304c\u5f90\u3005\u306b\u9032\u884c\u3059\u308b\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u7dda\u7dad\u75c7\u3092\u7d4c\u3066\u809d\u786c\u5909\u306b\u81f3\u308b\u4eba\u306e\u307b\u3046\u304c\u591a\u3044<\/strong>\u300d\u3068\u3044\u3046\u8a18\u8ff0\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p>\u809d\u81d3\u306f\u300c<strong>\u6c88\u9ed9\u306e\u81d3\u5668<\/strong>\u300d\u3068\u547c\u3070\u308c\u3001\u3088\u307b\u3069\u306e\u3053\u3068\u304c\u306a\u3044\u9650\u308a\u97f3\u3092\u4e0a\u3052\u307e\u305b\u3093\u3002\u8102\u80aa\u809d\u3082\u3001\u75c7\u72b6\u304c\u51fa\u308b\u3053\u3068\u306f\u307e\u308c\u3067\u3059\uff08e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\uff09\u3002<\/p>\n<p>\u305d\u308c\u3067\u3082\u3001\u3067\u3059\u3002<\/p>\n<ul>\n<li><strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u306f\u3001\u65ad\u9152\u306e\u307f\u3067\u6cbb\u7652\u3057\u307e\u3059<\/strong>\uff08MSD\u30de\u30cb\u30e5\u30a2\u30eb\u5bb6\u5ead\u7248\uff09<\/li>\n<li>\u300c\u5b8c\u5168\u306b\u9577\u671f\u9593\u306e\u65ad\u9152\u306b\u6210\u529f\u3059\u308c\u3070\u3001\u809d\u81d3\u306e\u518d\u751f\u304c\u5341\u5206\u671f\u5f85\u3067\u304d\u3001\u4e00\u822c\u7684\u306b\u751f\u547d\u4e88\u5f8c\u306f\u826f\u597d\u300d\uff08e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\uff09<\/li>\n<li><strong>\u7981\u91521\u5e74\u306b\u3064\u304d\u3001\u809d\u81d3\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f6\u301c7%\u4f4e\u4e0b\u3057\u307e\u3059<\/strong>\uff08e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\uff09<\/li>\n<li>\u6cbb\u7642\u306e\u57fa\u672c\u306f\u65ad\u9152\u3067\u3042\u308a\u3001\u6804\u990a\u7642\u6cd5\u3084\u85ac\u7269\u7642\u6cd5\u306f\u88dc\u52a9\u7684\u306a\u3082\u306e\uff08\u809d\u708e\u60c5\u5831\u30bb\u30f3\u30bf\u30fc\uff09<\/li>\n<\/ul>\n<p>\u300c\u58ca\u308c\u305f\u3089\u7d42\u308f\u308a\u300d\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u306d\u3002<strong>\u623b\u308b\u6bb5\u968e\u304c\u3042\u308b<\/strong>\u3001\u3068\u3044\u3046\u8a00\u3044\u65b9\u306e\u307b\u3046\u304c\u6b63\u78ba\u3067\u3059\u3002<\/p>\n<h2>\u3088\u304f\u3042\u308b\u8cea\u554f<\/h2>\n<p><strong>Q. \u4e8c\u65e5\u9154\u3044\u306e\u671d\u3001\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u3092\u98f2\u3093\u3067\u306f\u3044\u3051\u307e\u305b\u3093\u304b\u3002<\/strong><\/p>\n<p>\u300c\u98f2\u3093\u3060\u3089\u809d\u4e0d\u5168\u306b\u306a\u308b\u300d\u3068\u3044\u3046\u306e\u306f\u8a87\u5f35\u3067\u3059\u3002\u7528\u6cd5\u7528\u91cf\u3092\u5b88\u308c\u3070\u5e83\u304f\u4f7f\u308f\u308c\u3066\u3044\u308b\u85ac\u3067\u3059\u3002\u305f\u3060\u3057<strong>\u6162\u6027\u7684\u306a\u591a\u91cf\u98f2\u9152\u30fb\u7d76\u98df\u3084\u4f4e\u6804\u990a\u30fb\u8907\u6570\u306e\u5e02\u8ca9\u85ac\u306e\u91cd\u8907<\/strong>\u304c\u91cd\u306a\u308b\u3068\u809d\u81d3\u3078\u306e\u8ca0\u62c5\u304c\u8df3\u306d\u4e0a\u304c\u308b\u6761\u4ef6\u304c\u305d\u308d\u3044\u3001\u98f2\u9152\u306e\u7fcc\u671d\u306f\u305d\u306e\u6761\u4ef6\u304c\u91cd\u306a\u308a\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u6dfb\u4ed8\u6587\u66f8\u306e\u6307\u793a\u3092\u8d85\u3048\u305a\u3001\u4ed6\u306e\u85ac\u3068\u91cd\u306d\u306a\u3044\u3053\u3068\u3002\u5224\u65ad\u306b\u8ff7\u3046\u3068\u304d\u306f\u85ac\u5264\u5e2b\u30fb\u533b\u5e2b\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002<\/p>\n<p><strong>Q. \u3067\u306f NSAIDs\uff08\u30a4\u30d6\u30d7\u30ed\u30d5\u30a7\u30f3\u7b49\uff09\u306e\u307b\u3046\u304c\u5b89\u5168\u3067\u3059\u304b\u3002<\/strong><\/p>\n<p>\u305d\u3046\u3068\u306f\u8a00\u3048\u307e\u305b\u3093\u3002NSAIDs \u9577\u671f\u670d\u7528\u8005\u306e\u80c3\u6f70\u760d\u767a\u751f\u7387\u306f15.5\u301c30%\u3001\u4e0a\u90e8\u6d88\u5316\u7ba1\u51fa\u8840\u306e\u30aa\u30c3\u30ba\u6bd4\u306f6.1\u3067\u3001\u3057\u304b\u3082<strong>\u6f70\u760d\u306e42%\u306f\u7121\u75c7\u72b6<\/strong>\u3067\u3059\u3002\u98f2\u9152\u3067\u80c3\u7c98\u819c\u306f\u3059\u3067\u306b\u76f4\u63a5\u523a\u6fc0\u3092\u53d7\u3051\u3066\u3044\u307e\u3059\u3002<strong>\u3069\u3061\u3089\u304b\u304c\u5b89\u5168\u306a\u9003\u3052\u9053\u3001\u3068\u3044\u3046\u9078\u629e\u80a2\u306f\u5b58\u5728\u3057\u307e\u305b\u3093\u3002<\/strong><\/p>\n<p><strong>Q. \u4e8c\u65e5\u9154\u3044\u306e\u539f\u56e0\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3067\u306f\u306a\u3044\u306e\u3067\u3059\u304b\u3002<\/strong><\/p>\n<p>\u7fcc\u671d\u306e\u4e8c\u65e5\u9154\u3044\u306b\u3064\u3044\u3066\u306f\u3001\u305d\u3046\u8a00\u3044\u5207\u308c\u307e\u305b\u3093\u3002\u6442\u53d612\u6642\u9593\u5f8c\u306b\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u304c\u691c\u51fa\u3067\u304d\u306a\u304b\u3063\u305f\u3068\u3044\u3046\u5831\u544a\u304c\u3042\u308a\u3001\u75c7\u72b6\u306e\u30d4\u30fc\u30af\u6642\u306b\u306f\u307b\u307c\u6b8b\u3063\u3066\u3044\u307e\u305b\u3093\u3002\u8131\u6c34\u30fb\u4f4e\u8840\u7cd6\u30fb\u708e\u75c7\u30fb\u80c3\u7c98\u819c\u969c\u5bb3\u30fb\u6b8b\u5b58\u30a8\u30bf\u30ce\u30fc\u30eb\u7b49\u306e\u591a\u56e0\u5b50\u3067\u3059\u3002\u305f\u3060\u3057<strong>\u98f2\u9152\u4e2d\u301c\u76f4\u5f8c\u306b\u9854\u304c\u8d64\u304f\u306a\u308b\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\u306e\u4e3b\u5f79\u306f\u3001\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3067\u6b63\u3057\u3044<\/strong>\u3067\u3059\u3002<\/p>\n<p><strong>Q. \u6c34\u3092\u305f\u304f\u3055\u3093\u98f2\u3081\u3070\u65e9\u304f\u629c\u3051\u307e\u3059\u304b\u3002<\/strong><\/p>\n<p>\u629c\u3051\u307e\u305b\u3093\u3002e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u304c\u300c\u6c34\u3092\u305f\u304f\u3055\u3093\u98f2\u3080\u3068\u30a2\u30eb\u30b3\u30fc\u30eb\u304c\u901f\u304f\u306c\u3051\u308b\u3068\u52d8\u9055\u3044\u3057\u3066\u3044\u308b\u4eba\u3082\u3044\u307e\u3059\u300d\u3068\u660e\u8a18\u3057\u3066\u3044\u307e\u3059\u3002\u5206\u89e3\u901f\u5ea6\u306f\u4f53\u91cd\u00d70.1g\/\u6642 \u7a0b\u5ea6\u3067\u307b\u307c\u4e00\u5b9a\u3067\u3059\u3002\u6c34\u5206\u88dc\u7d66\u306f\u300c\u65e9\u304f\u629c\u304f\u305f\u3081\u300d\u3067\u306f\u306a\u304f\u300c\u8131\u6c34\u3092\u88dc\u3046\u305f\u3081\u300d\u306b\u610f\u5473\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p><strong>Q. \u30b5\u30a6\u30ca\u3084\u904b\u52d5\u3067\u6c57\u3092\u304b\u304f\u306e\u306f\u3069\u3046\u3067\u3059\u304b\u3002<\/strong><\/p>\n<p>\u539a\u751f\u52b4\u50cd\u7701\u306e\u98f2\u9152\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u3001<strong>\u98f2\u9152\u4e2d\u30fb\u98f2\u9152\u5f8c\u306e\u904b\u52d5\u30fb\u5165\u6d74\u3092\u907f\u3051\u308b\u3079\u304d\u98f2\u307f\u65b9<\/strong>\u3068\u3057\u3066\u6319\u3052\u3066\u3044\u307e\u3059\u3002\u6c57\u304b\u3089\u306e\u6392\u6cc4\u306f\u308f\u305a\u304b\u3067\u3001\u5fc3\u81d3\u3084\u8840\u5727\u3078\u306e\u8ca0\u62c5\u304c\u5897\u3048\u308b\u3060\u3051\u3067\u3059\u3002<\/p>\n<p><strong>Q. \u9854\u304c\u8d64\u304f\u306a\u308b\u306e\u306f\u3001\u5358\u306b\u304a\u9152\u306b\u5f31\u3044\u3060\u3051\u3067\u3059\u304b\u3002<\/strong><\/p>\n<p>\u305d\u308c\u3060\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002<strong>\u65e5\u672c\u4eba\u306e\u7d0440%\u306f ALDH2 \u306e\u50cd\u304d\u304c\u5f31\u304f\u3001\u30b3\u30c3\u30d71\u676f\u306e\u30d3\u30fc\u30eb\u3067\u9854\u304c\u8d64\u304f\u306a\u308b\u4eba\u306f\u7d049\u5272\u306e\u78ba\u7387\u3067\u8a72\u5f53<\/strong>\u3057\u307e\u3059\u3002\u30a8\u30bf\u30ce\u30fc\u30eb\u3082\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u3082\u767a\u304c\u3093\u6027\u7269\u8cea\u3067\u3042\u308a\u3001\u3053\u306e\u4f53\u8cea\u3067\u306f<strong>\u98df\u9053\u304c\u3093\uff08\u6241\u5e73\u4e0a\u76ae\u304c\u3093\uff09\u30fb\u982d\u9838\u90e8\u304c\u3093<\/strong>\u306e\u30ea\u30b9\u30af\u304c\u7279\u306b\u9ad8\u307e\u308b\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<p><strong>Q. \u809d\u81d3\u306e\u305f\u3081\u306b\u30a6\u30b3\u30f3\u3092\u98f2\u3080\u306e\u306f\u3069\u3046\u3067\u3059\u304b\u3002<\/strong><\/p>\n<p>\u65e5\u672c\u809d\u81d3\u5b66\u4f1a\u306e\u5831\u544a\u3067\u306f\u3001\u5065\u5eb7\u98df\u54c1\u306b\u3088\u308b\u85ac\u7269\u6027\u809d\u969c\u5bb3\u306e\u8d77\u56e0\u7269\u8cea\u3068\u3057\u3066<strong>\u30a6\u30b3\u30f3\u304c\u6700\u591a\uff0829\u4ef6\u30fb25%\uff09<\/strong>\u3067\u3057\u305f\u3002\u6ce8\u610f\u3059\u3079\u304d\u4eba\u3068\u3057\u3066\u300c\u9577\u5e74\u306b\u308f\u305f\u308b\u98f2\u9152\u306e\u7fd2\u6163\u304c\u3042\u308b\u4eba\u300d\u304c\u6319\u3052\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u98f2\u9152\u7fd2\u6163\u306e\u3042\u308b\u65b9\u306f\u3001\u7279\u306b\u614e\u91cd\u306b\u5224\u65ad\u3057\u3066\u304f\u3060\u3055\u3044\u3002<\/p>\n<h2>\u307e\u3068\u3081 \u2014 \u4eca\u671d\u306e\u982d\u75db\u3068\u3001\u6570\u5341\u5e74\u5f8c\u306e\u8acb\u6c42\u66f8<\/h2>\n<p>\u9577\u304f\u306a\u3063\u305f\u306e\u3067\u3001\u8981\u70b9\u3060\u3051\u7f6e\u3044\u3066\u304a\u304d\u307e\u3059\u3002<\/p>\n<ul>\n<li><strong>\u7fcc\u671d\u306e\u4e8c\u65e5\u9154\u3044\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306e\u305b\u3044\u3067\u306f\u306a\u3044<\/strong>\uff08\u6442\u53d612\u6642\u9593\u5f8c\u306b\u306f\u691c\u51fa\u4e0d\u80fd\uff09\u3002\u8131\u6c34\u30fb\u4f4e\u8840\u7cd6\u30fb\u708e\u75c7\u30fb\u80c3\u7c98\u819c\u969c\u5bb3\u30fb\u6b8b\u5b58\u30a8\u30bf\u30ce\u30fc\u30eb\u7b49\u306e<strong>\u591a\u56e0\u5b50<\/strong><\/li>\n<li>\u305f\u3060\u3057<strong>\u98f2\u9152\u4e2d\u301c\u76f4\u5f8c\u306e\u30d5\u30e9\u30c3\u30b7\u30f3\u30b0\u53cd\u5fdc\u306e\u4e3b\u5f79\u306f\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9<\/strong>\u3002\u3053\u306e\u533a\u5225\u304c\u8981<\/li>\n<li>\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u306f\u7528\u6cd5\u7528\u91cf\u3092\u5b88\u308c\u3070\u5e83\u304f\u4f7f\u308f\u308c\u308b\u85ac\u3002<strong>\u300c\u7fcc\u671d\u306e1\u56de\u3067\u809d\u4e0d\u5168\u300d\u306f\u8a87\u5f35<\/strong>\u3002\u5371\u967a\u304c\u96c6\u4e2d\u3059\u308b\u306e\u306f<strong>\u2460\u6162\u6027\u591a\u91cf\u98f2\u9152 \u2461\u7d76\u98df\u30fb\u4f4e\u6804\u990a \u2462\u8907\u6570\u306e\u5e02\u8ca9\u85ac\u306e\u91cd\u8907<\/strong><\/li>\n<li><strong>\u4e2d\u6bd2\u306e\u7b2cI\u671f\uff080\u301c24\u6642\u9593\uff09\u306e\u75c7\u72b6\u306f\u98df\u6b32\u4e0d\u632f\u30fb\u60aa\u5fc3\u30fb\u5614\u5410<\/strong> \u2014 \u4e8c\u65e5\u9154\u3044\u3068\u898b\u5206\u3051\u304c\u3064\u304b\u306a\u3044\u3002\u3053\u308c\u304c\u300c\u9759\u304b\u306b\u58ca\u308c\u308b\u300d\u3068\u3044\u3046\u3053\u3068<\/li>\n<li><strong>NSAIDs \u3082\u9003\u3052\u9053\u3067\u306f\u306a\u3044<\/strong>\uff08\u6f70\u760d\u767a\u751f\u738715.5\u301c30%\u3001\u51fa\u8840\u30aa\u30c3\u30ba\u6bd46.1\u3001\u6f70\u760d\u306e42%\u304c\u7121\u75c7\u72b6\uff09<\/li>\n<li><strong>\u4e8c\u65e5\u9154\u3044\u5bfe\u7b56\u306b\u78ba\u7acb\u3057\u305f\u6839\u62e0\u306f\u306a\u3044<\/strong>\uff08BMJ 2005 \u306e8\u4ef6\u3001Addiction 2022 \u306e21\u4ef6\u3068\u3082\u300c\u6709\u52b9\u306e\u8a3c\u62e0\u306a\u3057\u300d\uff09<\/li>\n<li><strong>\u6c34\u30fb\u904b\u52d5\u30fb\u5165\u6d74\u3067\u4ee3\u8b1d\u306f\u52a0\u901f\u3057\u306a\u3044<\/strong>\u3002\u904b\u52d5\u30fb\u5165\u6d74\u306f\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u304c\u907f\u3051\u308b\u3079\u304d\u98f2\u307f\u65b9\u306b\u6319\u3052\u3066\u3044\u308b<\/li>\n<li><strong>\u65e5\u672c\u4eba\u306e\u7d0440%\u306f ALDH2 \u304c\u5f31\u3044\u3002\u30b3\u30c3\u30d71\u676f\u3067\u8d64\u304f\u306a\u308b\u306a\u3089\u7d049\u5272\u306e\u78ba\u7387\u3067\u8a72\u5f53<\/strong>\u3002\u3053\u306e\u4f53\u8cea\u3067\u306f\u98df\u9053\u304c\u3093\u30fb\u982d\u9838\u90e8\u304c\u3093\u306e\u30ea\u30b9\u30af\u304c\u7279\u306b\u9ad8\u3044<\/li>\n<li><strong>\u809d\u81d3\u306e\u305f\u3081\u306e\u30a6\u30b3\u30f3\u304c\u3001\u85ac\u7269\u6027\u809d\u969c\u5bb3\u306e\u8d77\u56e0\u7269\u8cea\u3068\u3057\u3066\u6700\u591a<\/strong>\u3068\u3044\u3046\u76ae\u8089<\/li>\n<li>\u305d\u308c\u3067\u3082<strong>\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u8102\u80aa\u809d\u306f\u65ad\u9152\u306e\u307f\u3067\u6cbb\u7652\u3057\u3001\u7981\u91521\u5e74\u3067\u809d\u81d3\u304c\u3093\u306e\u30ea\u30b9\u30af\u306f6\u301c7%\u4f4e\u4e0b\u3059\u308b<\/strong><\/li>\n<\/ul>\n<p>\u79c1\u304c\u3053\u306e\u8a18\u4e8b\u3092\u66f8\u304d\u306a\u304c\u3089\u3044\u3061\u3070\u3093\u843d\u3061\u7740\u304b\u306a\u304b\u3063\u305f\u306e\u306f\u3001\u300c\u7fcc\u671d\u3092\u3069\u3046\u3084\u308a\u904e\u3054\u3059\u304b\u300d\u3070\u304b\u308a\u8003\u3048\u3066\u3044\u305f\u81ea\u5206\u3067\u3057\u305f\u3002<\/p>\n<p>\u3084\u308a\u904e\u3054\u3059\u65b9\u6cd5\u306f\u3001\u7d50\u5c40\u306e\u3068\u3053\u308d\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002\u6642\u9593\u3057\u304b\u306a\u304b\u3063\u305f\u306e\u3067\u3059\u3002<\/p>\n<p>\u305d\u306e\u304b\u308f\u308a\u3001\u5225\u306e\u3053\u3068\u304c\u3072\u3068\u3064\u5206\u304b\u308a\u307e\u3057\u305f\u3002\u30a2\u30bb\u30c8\u30a2\u30eb\u30c7\u30d2\u30c9\u306f\u7fcc\u671d\u306e\u8acb\u6c42\u66f8\u3092\u9001\u3063\u3066\u304d\u307e\u305b\u3093\u3002\u3082\u3063\u3068\u5148\u306b\u3001\u307e\u3068\u3081\u3066\u9001\u3063\u3066\u304d\u307e\u3059\u3002<\/p>\n<p>\u3060\u3068\u3059\u308c\u3070\u3001\u3044\u307e\u898b\u76f4\u3059\u3079\u304d\u306a\u306e\u306f\u4eca\u671d\u306e\u85ac\u7bb1\u3067\u306f\u306a\u304f\u3001<strong>\u4eca\u591c\u306e\u4e00\u676f\u306e\u307b\u3046<\/strong>\u306a\u306e\u304b\u3082\u3057\u308c\u307e\u305b\u3093\u3002\u4eca\u671d\u306e\u982d\u75db\u306f\u3001\u653e\u3063\u3066\u304a\u3044\u3066\u3082\u3044\u305a\u308c\u6d88\u3048\u3066\u3044\u304d\u307e\u3059\u304b\u3089\u3002<\/p>\n<hr \/>\n<p><strong>\u3054\u78ba\u8a8d\u304f\u3060\u3055\u3044\uff08\u53d7\u8a3a\u30fb\u6551\u6025\u306e\u76ee\u5b89\uff09<\/strong><\/p>\n<p>\u6b21\u306e\u3044\u305a\u308c\u304b\u306b\u5f53\u3066\u306f\u307e\u308b\u3068\u304d\u306f\u3001\u81ea\u5df1\u5224\u65ad\u3067\u69d8\u5b50\u3092\u898b\u305a\u3001\u6551\u6025\u8981\u8acb\uff08119\uff09\u307e\u305f\u306f\u533b\u7642\u6a5f\u95a2\u306e\u53d7\u8a3a\u3092\u3054\u691c\u8a0e\u304f\u3060\u3055\u3044\u3002<\/p>\n<ul>\n<li><strong>\u547c\u3073\u304b\u3051\u306b\u53cd\u5fdc\u3057\u306a\u3044\uff0f\u547c\u5438\u304c\u304a\u304b\u3057\u3044\uff0f\u4f53\u304c\u51b7\u305f\u3044\uff0f\u75d9\u6523\u3057\u3066\u3044\u308b<\/strong>\uff08\u6025\u6027\u30a2\u30eb\u30b3\u30fc\u30eb\u4e2d\u6bd2\u306e\u7591\u3044\u3002<strong>\u6c7a\u3057\u3066\u4e00\u4eba\u306b\u3057\u3066\u653e\u7f6e\u3057\u306a\u3044<\/strong>\u3001\u6a2a\u5411\u304d\u306e\u56de\u5fa9\u4f53\u4f4d\u306b\u3057\u3066\u4fdd\u6e29\u3059\u308b\uff09<\/li>\n<li><strong>\u5410\u8840\u3001\u9ed2\u8272\u4fbf\uff08\u4e0b\u8840\uff09<\/strong><\/li>\n<li><strong>\u9ec4\u75b8\uff08\u76ae\u819a\u3084\u767d\u76ee\u306e\u9ec4\u67d3\uff09\u3001\u8910\u8272\u5c3f<\/strong><\/li>\n<li><strong>\u6fc0\u3057\u3044\u8179\u75db\u3001\u7279\u306b\u53f3\u4e0a\u8179\u90e8\u306e\u75db\u307f<\/strong><\/li>\n<li><strong>\u6301\u7d9a\u3059\u308b\u5026\u6020\u611f\u3001\u98df\u6b32\u4e0d\u632f\u3001\u767a\u71b1\u3001\u767a\u75b9<\/strong><\/li>\n<li><strong>\u85ac\u3092\u98f2\u307f\u3059\u304e\u305f\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u601d\u3063\u305f\u3068\u304d<\/strong>\uff08\u75c7\u72b6\u304c\u8efd\u304f\u3066\u3082\u3001\u7121\u75c7\u72b6\u3067\u3082\uff09<\/li>\n<\/ul>\n<p><strong>\u514d\u8cac\u4e8b\u9805<\/strong>\uff1a\u672c\u8a18\u4e8b\u306f\u4e00\u822c\u7684\u306a\u5065\u5eb7\u60c5\u5831\u306e\u63d0\u4f9b\u3092\u76ee\u7684\u3068\u3057\u305f\u3082\u306e\u3067\u3042\u308a\u3001\u8a3a\u65ad\u30fb\u6cbb\u7642\u30fb\u670d\u85ac\u6307\u5c0e\u306e\u4ee3\u308f\u308a\u306b\u306a\u308b\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u85ac\u306e\u4f7f\u7528\u306b\u3064\u3044\u3066\u306f\u6dfb\u4ed8\u6587\u66f8\u306b\u5f93\u3044\u3001\u5224\u65ad\u306b\u8ff7\u3046\u5834\u5408\u306f\u533b\u5e2b\u30fb\u85ac\u5264\u5e2b\u306b\u3054\u76f8\u8ac7\u304f\u3060\u3055\u3044\u3002\u98f2\u9152\u7fd2\u6163\u3084\u6301\u75c5\u306e\u3042\u308b\u65b9\u3001\u4ed6\u306b\u670d\u7528\u4e2d\u306e\u85ac\u304c\u3042\u308b\u65b9\u3001\u598a\u5a20\u30fb\u6388\u4e73\u4e2d\u306e\u65b9\u306f\u3001\u7279\u306b\u81ea\u5df1\u5224\u65ad\u3092\u907f\u3051\u3066\u304f\u3060\u3055\u3044\u3002\u672c\u8a18\u4e8b\u3067\u306f\u610f\u56f3\u7684\u306b\u3001\u85ac\u5264\u306e\u7528\u91cf\u30fb\u88fd\u54c1\u540d\u30fb\u30d6\u30e9\u30f3\u30c9\u540d\u3092\u8a18\u8f09\u3057\u3066\u3044\u307e\u305b\u3093\u3002<\/p>\n<blockquote>\n<p><strong>\u53c2\u8003\u8cc7\u6599<\/strong>\uff1aPMDA\uff0fJAPIC \u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u539f\u672b \u6dfb\u4ed8\u6587\u66f8\uff08\u8b66\u544a\u30fb\u7279\u5b9a\u306e\u80cc\u666f\u3092\u6709\u3059\u308b\u60a3\u8005\u30fb\u4f75\u7528\u6ce8\u610f\u30fb\u91cd\u5927\u306a\u526f\u4f5c\u7528\uff09\u3001\u539a\u751f\u52b4\u50cd\u7701 e-\u30d8\u30eb\u30b9\u30cd\u30c3\u30c8\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u304c\u3093\u300d\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u3068\u809d\u81d3\u75c5\u300d\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u306e\u5438\u53ce\u3068\u5206\u89e3\u300d\u3001\u539a\u751f\u52b4\u50cd\u7701\u300e\u5065\u5eb7\u306b\u914d\u616e\u3057\u305f\u98f2\u9152\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u300f\uff082024\u5e742\u670819\u65e5\u516c\u8868\uff09\u3001\u56fd\u7acb\u5065\u5eb7\u5371\u6a5f\u7ba1\u7406\u7814\u7a76\u6a5f\u69cb \u809d\u708e\u60c5\u5831\u30bb\u30f3\u30bf\u30fc\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u969c\u5bb3\u300d\u3001\u56fd\u7acb\u9577\u5bff\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc\u300c\u85ac\u5264\u6027\u6d88\u5316\u7ba1\u969c\u5bb3\uff08NSAIDs \u3068\u6297\u8840\u5c0f\u677f\u85ac\uff09\u300d\u3001MSD\u30de\u30cb\u30e5\u30a2\u30eb \u30d7\u30ed\u30d5\u30a7\u30c3\u30b7\u30e7\u30ca\u30eb\u7248\u300c\u30a2\u30bb\u30c8\u30a2\u30df\u30ce\u30d5\u30a7\u30f3\u4e2d\u6bd2\u300d\u3001MSD\u30de\u30cb\u30e5\u30a2\u30eb\u5bb6\u5ead\u7248\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u6027\u809d\u75be\u60a3\u300d\u3001\u6e08\u751f\u4f1a\u300c\u98f2\u307f\u3059\u304e\u6ce8\u610f\uff01\u6025\u6027\u30a2\u30eb\u30b3\u30fc\u30eb\u4e2d\u6bd2\u30fb\u4e88\u9632\u306e\u30b9\u30b9\u30e1\u300d\u3001\u4e00\u6a4b\u5927\u5b66\u4fdd\u5065\u30bb\u30f3\u30bf\u30fc\u300c\u30a2\u30eb\u30b3\u30fc\u30eb\u306b\u3064\u3044\u3066\u300d\u3001\u4e45\u91cc\u6d5c\u533b\u7642\u30bb\u30f3\u30bf\u30fc \u6728\u6751\u5145\u533b\u5e2b\u30b3\u30e1\u30f3\u30c8\uff08\u65e5\u672c\u7d4c\u6e08\u65b0\u805e NIKKEI STYLE\uff09\u3001\u65e5\u672c\u809d\u81d3\u5b66\u4f1a \u6edd\u5ddd\u4e00\u533b\u5e2b\u306e\u5831\u544a\uff08\u7cd6\u5c3f\u75c5\u30cd\u30c3\u30c8\u30ef\u30fc\u30af\uff09\u3001Pittler MH et al. BMJ. 2005\uff08PMC1322250\uff09\u3001Roberts E et al. Addiction. 2022\uff08NIHR ARC South London\uff09\u3001van de Loo AJAE et al. J Clin Med. 2020;9(7):2081\u3001Ylikahri R et al. 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